2-Fluorophenol

2-Fluorophenol Chemical Properties
Melting point 16.1 °C (lit.)
Boiling point 171-172 °C/741 mmHg (lit.)
density 1.256 g/mL at 25 °C (lit.)
refractive index n20/D 1.511(lit.)
Fp 116 °F
storage temp. Inert atmosphere,Room Temperature
solubility 37.7g/l
form Liquid
pka8.73(at 25℃)
color Clear colorless to light yellow-brownish
Specific Gravity1.256
Water Solubility 80.72g/L(25 ºC)
BRN 1905112
Stability:Stable. Flammable. Incompatible with strong oxidizing agents.
InChIKeyHFHFGHLXUCOHLN-UHFFFAOYSA-N
CAS DataBase Reference367-12-4(CAS DataBase Reference)
NIST Chemistry ReferencePhenol, 2-fluoro-(367-12-4)
EPA Substance Registry Systemo-Fluorophenol (367-12-4)
Safety Information
Hazard Codes Xn,F,C,Xi,T
Risk Statements 20/21/22-36/37/38-10-63-43-23/24/25-45-40
Safety Statements 28-36/37-36/37/39-26-16-24/25-23-53-36
RIDADR UN 1993 3/PG 3
WGK Germany 3
RTECS SL4530000
Hazard Note Flammable/Corrosive
TSCA T
HazardClass 3
PackingGroup III
HS Code 29081000
MSDS Information
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2-Fluorophenol English
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2-Fluorophenol Usage And Synthesis
Chemical PropertiesClear colourless to yellow liquid
Uses2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria.
Synthesis Reference(s)Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015
General DescriptionLiquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3.
Air & Water ReactionsHighly flammable.
Reactivity Profile2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid.
Health HazardACUTE/CHRONIC HAZARDS: Toxic and irritant.
Purification MethodsPass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.]
Pentafluorophenol SODIUM PHENOLATE TRIHYDRATE 2-Brome-5-Fluorophenol,2-Bromo-5-fluorophenol 98% 2,6-Difluorophenol Guaiacol 3,4-Difluorophenol 2,6-Dimethylphenol 2-Nitrophenol 2-Fluorobenzyl cyanide o-Cresol 2-tert-Butylphenol 2-Chloro-4-fluorophenol 99% 2-Bromophenol 2-Aminophenol 3,4,5-Trifluorophenol 2,6-DINITROPHENOL p-Fluorophenol,99%,4-Fluorophenol,99% 2-Ethoxyphenol

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