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| | Sulbactam sodium Basic information |
| Product Name: | Sulbactam sodium | | Synonyms: | SULBACTAM SODIUM;SULBACTAM SODIUM SALT;sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S,5R)- (9CI);(2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid 4,4-dioxide sodium salt;sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide;sulbacyam sodium;AMPICILLIN SODIUM AND SULBACTAM SODIUM 2:1 | | CAS: | 69388-84-7 | | MF: | C8H12NNaO5S | | MW: | 257.24 | | EINECS: | 273-984-4 | | Product Categories: | pharmaceutical raw material;Antibiotic;Pharmaceutical raw materials;Inhibitors;Pharma;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API;APIs;69388-84-7 | | Mol File: | 69388-84-7.mol |  |
| | Sulbactam sodium Chemical Properties |
| Melting point | >230°C (dec.) | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | Freely soluble in water, sparingly soluble in ethyl acetate, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute acids. | | form | neat | | color | White | | InChIKey | NKZMPZCWBSWAOX-IBTYICNHSA-M | | CAS DataBase Reference | 69388-84-7(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 42/43 | | Safety Statements | 22-24-36/37-45-24/25 | | HS Code | 29349990 | | Toxicity | LD50 ivn-rat: 6500 mg/kg NKRZAZ 32(Suppl 4),97,84 |
| | Sulbactam sodium Usage And Synthesis |
| Description | Sulbactam sodium is a parenterally-active, β-lactamase inhibitor recently
introduced as a 1: 1 combination product with cefoperazone. Like clavulanic acid,
the first agent of this type to b e introduced, sulbactam enhances the effectiveness
of β-lactam antibiotics against resistant strains. | | Chemical Properties | White Solid | | Originator | Pfizer (USA) | | Uses | A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial. | | Definition | ChEBI: Sulbactam sodium is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid. | | Manufacturing Process | Sulbactam sodium is semi-synthetic antibiotic of penicillinic group. Start
material for it's synthesis is 6-aminopenicillanic acid. First 6-aminopenicillanic
acid was isolated in 1957 year from benzylpenicilline as resalt of treating of it
by penicillinaze. Benzylpenicilline is produced by microorganism of genus
Streptomyces.
Further, 6-aminopenicillanic acid reacted with bromine, hydrochloric acid and
NaNO2. As a result the 6,6-dibromopenicillanic acid was obtained.
6,6-Dibromopenicillanic acid was oxidized by KMnO4, to give 6,6-dibromo-1,1-The 6,6-dibromo-1,1-dioxopenicillanic acid in presence of Fe was converted to
the 1,1-dioxopenicillanic acid (sulbactam acid). The sulbactam acid was
treated by sodium 2-ethylhexanoate and crude sulbactam sodium was
obtained. | | Brand name | SULPERAZONE | | Therapeutic Function | Beta-lactamase inhibitor | | Safety Profile | Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx |
| | Sulbactam sodium Preparation Products And Raw materials |
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