Fluphenazine decanoate

Fluphenazine decanoate Basic information
Product Name:Fluphenazine decanoate
Synonyms:FluphenazineCecanoate;FLUPHENAZINEDECANATE;Decanoic acid, 2-[4-[3-[2-(trifluoromethyl) -10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl ester;Decanoic acid 2-[4-[3-(2-trifluoromethyl-10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethyl ester;Decanoic acid fluphenazine;2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyld;dapotumd;decanoicacid,2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-pipera
CAS:5002-47-1
MF:C32H44F3N3O2S
MW:591.77
EINECS:225-672-4
Product Categories:Organics;API
Mol File:5002-47-1.mol
Fluphenazine decanoate Structure
Fluphenazine decanoate Chemical Properties
Melting point 30-32°
Boiling point 658.1±55.0 °C(Predicted)
density 1.149±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol.
form neat
pka7.32±0.10(Predicted)
CAS DataBase Reference5002-47-1
Safety Information
RIDADR 3249
RTECS HE0525000
HazardClass 6.1(a)
PackingGroup II
MSDS Information
Fluphenazine decanoate Usage And Synthesis
Chemical PropertiesYellow Oil
UsesFluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.
DefinitionChEBI: Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a prodrug and a dopaminergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine. It is functionally related to a fluphenazine.
Clinical UseAntipsychoticSchizophrenia and other psychoses
Drug interactionsPotentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids. Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval; increased risk of ventricular arrhythmias with amiodarone and dronedarone - avoid; increased risk of ventricular arrhythmias with disopyramide.Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid Antidepressants: increased risk of ventricular arrhythmias with tricyclics, citalopram, escitalopram; possible increased risk of convulsions with vortioxetineAntiepileptics: antagonises anticonvulsant effect.Antimalarials: increased risk of ventricular arrhythmias with artenimol with piperaquine and artemether/lumefantrine - avoid.Antipsychotics: increased risk of ventricular arrhythmias with droperidol, pimozide and risperidone - avoid; avoid use of depot formulations with clozapine (cannot be withdrawn quickly if neutropenia occurs).Antivirals: increased risk of ventricular arrhythmias with saquinavir - avoid; concentration possibly increased with ritonavir.Anxiolytics and hypnotics: increased sedative effectsAtomoxetine: increased risk of ventricular arrhythmias.Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalolCytotoxics: increased risk of ventricular arrhythmias with arsenic trioxideDiuretics: enhanced hypotensive effect.Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.Pentamidine: increased risk of ventricular arrhythmias - avoid.Avoid with drugs that prolong the QT interval.
MetabolismThe cytochrome P450 isoenzyme CYP2D6 is involved in fluphenazine metabolism.
Fluphenazine decanoate Preparation Products And Raw materials
Piperacillin Fluphenazine decanoate 10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine 1-[2-(1-PROPYL)-OXYETHYL]-PIPERAZINE Levodropropizine N-Aminoethylpiperazine 1-(2-ETHOXYETHYL)PIPERAZINE Phenothiazine [(3S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] decanoate fluphenazine O-enantate FLUPHENAZINE HYDROCHLORIDE 2-(Trifluoromethyl)phenothiazine Piperazine FLUPHENAZINE Prochlorperazine Fluphenazine Decanoate Injection, USP Trifluoperazine triflupromazine

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