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| | AFLATOXIN B2 Basic information |
| Product Name: | AFLATOXIN B2 | | Synonyms: | AFLATOXIN B2;(6ar-cis)-hexahydro-4-methoxy;,9,9a-alpha-hexahydro-4-methoxy-;2,3,6aalpha,8,9,9aalpha-hexahydro-4-methoxycyclopenta(c)furo(3’,2’:4,5)furo(2,;Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6aalpha,8,9,9aalpha-hexahydro-4-methoxy-;Dihydroafflatoxin B1;Dihydroaflatoxin B1;dihydroaflatoxinb1 | | CAS: | 7220-81-7 | | MF: | C17H14O6 | | MW: | 314.29 | | EINECS: | 230-618-8 | | Product Categories: | Other;antibiotic;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Biotoxins;Mycotoxins;Single component solutions;Cancer Research;CarcinogensCell Signaling and Neuroscience;Mold;Toxins and Venoms;Pharmaceuticals;CRM&Matrix RMApplication CRMs;A;AA to ALBiotoxins;Alphabetic;Food and Agriculture CRM | | Mol File: | 7220-81-7.mol |  |
| | AFLATOXIN B2 Chemical Properties |
| Melting point | 286-289 °C | | alpha | D -492° (c = 0.1 in CHCl3) | | Boiling point | 373.98°C (rough estimate) | | density | 1.2564 (rough estimate) | | refractive index | 1.4800 (estimate) | | Fp | 11 °C | | storage temp. | 2-8°C | | solubility | DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12 mg/ml | | form | neat | | Water Solubility | 15mg/L(temperature not stated) | | Merck | 13,180 | | BRN | 1355115 | | LogP | 1.802 (est) | | CAS DataBase Reference | 7220-81-7 |
| | AFLATOXIN B2 Usage And Synthesis |
| Chemical Properties | off-white powder | | Chemical Properties | The aflatoxins are a group of molds produced by the fungus Aspergillus flavus. They are natural contaminants of fruits, vegetables, and grains. They are also described as a series of condensed ring heterocyclic compounds. They form colorless to pale yellow crystals. Practically insoluble in water. | | Uses | Aflatoxins are naturally occuring mycotoxins produced by various species of the mold Aspergillus, which can be found in legumes, corn, soybeans, rice, milk, and cheese. They are highly carcinogenic substances that are metabolized by the liver to a reactive epoxide intermediate, which produces adducts that modify DNA. Aflatoxin B1 induces transversion of G to T at codon 249 of the p53 tumor suppressor gene. This transversion is common in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination. Aflatoxin B2 is the dihydro derivative of aflatoxin B1, a naturally occuring mycotoxin and food contaminant that is a likely pathogen that causes hepatocellular carcinoma.[Cayman Chemical] | | Uses | Aflatoxins B1, B2, G1, G2 as secondary metabolites of fungal species such as Aspergillus flavus or Aspergillus parasiticus growing on a variety of foods (peanuts, nuts, spices, cereals). Aflatoxins are a group of very carcinogenic mycotoxins with hepatotoxic effects. | | Uses | Aflatoxin B2 is the minor analogue of the blue fluorescent family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species. Alfatoxins are one of the most potent mycotoxins known but are in fact "pre-toxins", requiring metabolic activation to the toxic principle. Aflatoxins are found widely in nature in trace amounts, particularly in grains and nuts. The toxicity of these metabolites was first recognised in the 1950s and their structures elucidated in 1963. Aflatoxins have been extensively reviewed. | | Definition | ChEBI: An aflatoxin having a hexahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11. | | General Description | Aflatoxin B2 is one of the fungal metabolic products produced in food and feed, contaminated by?Aspergillus?species. | | Safety Profile | Confirmed human carcinogen with experimental tumorigenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also various aflatoxins.
| | Potential Exposure | Aflatoxins are a group of toxic metabolites produced by certain types of fungi. Aflatoxins are not commercially manufactured; they are naturally occurring contaminants that are formed by fungi on food during conditions of high temperatures and high humidity. Most human exposure to aflatoxins occurs through ingestion of contaminated food. The estimated amount of aflatoxins that Americans consume daily is estimated to be 0.15 0.50 μg. Grains, peanuts, tree nuts, and cottonseed meal are among the more common foods on which these fungi grow. Meat, eggs, milk, and other edible products from animals that consume aflatoxincontaminated feed may also contain aflatoxins. Aflatoxins can also be breathed in | | Shipping | UN3172 Toxins, extracted from living sources, solid or liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. | | Incompatibilities | Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
| | Waste Disposal | Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Use of oxidizing agents, such as hydrogen peroxide or 5% sodium hypochlorite bleach. Acids and bases may also be used. |
| | AFLATOXIN B2 Preparation Products And Raw materials |
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