ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Methylpyridine 4-Methylpyridin-2-amine

4-Methylpyridin-2-amine

4-Methylpyridin-2-amine Basic information
Product Name:4-Methylpyridin-2-amine
Synonyms:2-amino-4-methyl-pyridin;2-amino-4-picolin;2-Amino-gamma-picoline;2-Aminop-4-picoline;2-Pyridinamine,4-methyl-;w45;w45raschig;4-METHYL-2-PYRIDYLAMINE
CAS:695-34-1
MF:C6H8N2
MW:108.14
EINECS:211-780-9
Product Categories:amine;Amines;Pyridines derivates;Aromatics;Heterocycles;Miscellaneous Reagents;VARIOUSAMINE;FINE Chemical & INTERMEDIATES;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines;bc0001
Mol File:695-34-1.mol
4-Methylpyridin-2-amine Structure
4-Methylpyridin-2-amine Chemical Properties
Melting point 96-99 °C (lit.)
Boiling point 230 °C (lit.)
density 1.0275 (estimate)
vapor pressure 3.71Pa at 25℃
refractive index 1.5560 (estimate)
Fp 118 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMF: freely soluble
form Flakes
pkapK1: 7.48(+1) (25°C)
color Slightly yellow to beige or brown
Water Solubility SOLUBLE
Sensitive Hygroscopic
Merck 14,466
BRN 107066
LogP0.56-1.08
CAS DataBase Reference695-34-1(CAS DataBase Reference)
NIST Chemistry Reference2-Pyridinamine, 4-methyl-(695-34-1)
EPA Substance Registry System2-Pyridinamine, 4-methyl- (695-34-1)
Safety Information
Hazard Codes T
Risk Statements 45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25
Safety Statements 53-45-60-61-37/39-28A-26-36/37/39
RIDADR UN 3086 6.1/PG 1
WGK Germany 3
RTECS TJ5150000
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29333999
ToxicityLD50 oral in rat: 200mg/kg
MSDS Information
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4-Methylpyridin-2-amine Usage And Synthesis
Chemical PropertiesLight yellow to brown flakes
UsesIntermediate, medicine.
Uses2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.
Synthesis Reference(s)The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
General Description2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.
Biochem/physiol Actions2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.
Purification MethodsCrystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]
4-Methylpyridin-2-amine Preparation Products And Raw materials
Preparation Products2-BROMO-3-IODO-ISONICOTINIC ACID-->2-CHLORO-3-HYDROXYISONICOTINIC ACID-->2-AMINO-ISONICOTINIC ACID HYDRAZIDE-->2-AMINO-ISONICOTINIC ACID ETHYL ESTER-->2-ACETAMIDO-5-BROMOISONICOTINIC ACID-->2-Nitropyridine-4-carboxylic acid-->(2-AMINO-PYRIDIN-4-YL)-METHANOL-->2-AMINO-5-FLUORO-4-PICOLINE-->2-Aminoisonicotinic acid-->2-Fluoroisonicotinic acid-->2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID-->4-Pyridinecarbonyl chloride, 2-fluoro- (9CI)-->2-AMINO-3,5-DICHLORO-4-METHYLPYRIDINE-->2-ACETAMIDO-5-AMINO-4-PICOLINE-->2-ACETAMIDO-5-NITRO-4-PICOLINE-->2-HYDROXY-4-PYRIDINECARBOXALDEHYDE-->2-ACETAMIDO-4-METHYL-5-BROMOPYRIDINE-->2-Bromo-4-methylpyridine-->2-Amino-5-nitro-4-picoline-->2-Acetylamino-4-methylpyridine-->2-Amino-5-bromo-4-methylpyridine
1-(6-METHYL-4-(TRIFLUOROMETHYL)PYRID-2-YL)-1-METHYLHYDRAZINE CHEMBRDG-BB 9070478 4-[(4-METHYL-2-PYRIDINYL)AMINO]-4-OXOBUTANOIC ACID LABOTEST-BB LT00012626 2-Amino-4,6-dimethylpyridine 6-METHYL-4-(TRIFLUOROMETHYL)PYRID-2-YL HYDRAZINE 4,6-DIMETHYL-2-MORPHOLINONICOTINONITRILE 2-(DIMETHYLAMINO)-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE 2-Amino-5-bromo-4-methyl-3-nitropyridine 2-Amino-3-nitro-4-picoline 6-amino-2,4-dimethylnicotinonitrile 2-Amino-4-(trifluoromethyl)pyridine N'3-[6-METHYL-4-(TRIFLUOROMETHYL)-2-PYRIDYL]-5-CHLORO-1-METHYL-1H-PYRAZOLE-3-CARBOHYDRAZIDE 2-(1-METHYLHYDRAZINO)-4-(TRIFLUOROMETHYL)PYRIDINE 4,6-DIMETHYL-2-PIPERIDINONICOTINONITRILE 4-Picoline, 2-(benzylamino)- 6-HYDRAZINO-1,3,4-TRIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE 4-Methylpyridin-2-amine
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