|
| | Phenyl carbamate Basic information |
| | Phenyl carbamate Chemical Properties |
| Melting point | 149-152 °C(lit.) | | Boiling point | 251.96°C (rough estimate) | | density | 1.2528 (rough estimate) | | refractive index | 1.5030 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.33±0.50(Predicted) | | Water Solubility | Soluble in water. | | BRN | 2042627 | | CAS DataBase Reference | 622-46-8(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29242998 |
| | Phenyl carbamate Usage And Synthesis |
| Chemical Properties | white to very slightly pink crystalline flakes | | Uses | Phenyl carbamate is used as various phenyl carbamate esters derived from amino acids, a dipeptide and amino acid esters and amides were prepared and assessed as potential prodrugs with the aim of protecting phenolic drugs against first-pass metabolism following per oral administration.
A tin-catalyzed transcarbamoylation of primary and secondary alcohols with phenyl carbamate proceeds smoothly in toluene at 90℃ to generate the corresponding carbamates in good yields. This mild method exhibits a broad functional-group tolerance.
Y. Ichikawa, Y. Morishita, S. Kusaba, N. Sakiyama, Y. Matsuda, K. Nakano, H. Kotsuki, Synlett, 2010, 1815-1818.
http://dx.doi.org/10.1055/s-0030-1258102 | | Uses | Phenyl Carbamate is a robust, inert to Pd-catalysis reagent which are useful for arene functionalization/site-selective cross-coupling reactions. | | Definition | ChEBI: Phenyl carbamate is an aromatic ether. |
| | Phenyl carbamate Preparation Products And Raw materials |
|
