Methyl diethylphosphonoacetate

Methyl diethylphosphonoacetate Basic information

Product Name:	Methyl diethylphosphonoacetate
Synonyms:	Diethyl methoxycarbonylmethanephosphonate for synthesis;Acetic acid, (diethoxyphosphinyl)-, methyl ester;Diethyl carbomethoxymethylphosphonate;Methyl (diethoxyphosphoryl)acetate;APAZ-027;METHYL P,P-DIETHYLPHOSPHONOACETATE;METHYL DIETHYLPHOSPHONOACETATE;LABOTEST-BB LT00452673
CAS:	1067-74-9
MF:	C7H15O5P
MW:	210.16
EINECS:	213-938-2
Product Categories:	Horner-Emmons Reaction;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction
Mol File:	1067-74-9.mol

Methyl diethylphosphonoacetate Chemical Properties

Boiling point	127-131 °C9 mm Hg(lit.)
density	1.145 g/mL at 25 °C(lit.)
refractive index	n20/D 1.433(lit.)
Fp	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Miscible with tetrahydrofuran.
form	Liquid
color	Clear colorless to faint yellow
BRN	1782397
CAS DataBase Reference	1067-74-9(CAS DataBase Reference)
NIST Chemistry Reference	Acetic acid, phosphono-, p,p-diethyl c-methyl ester(1067-74-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	10
HS Code	29310095

MSDS Information

Provider	Language
Methyl diethylphosphonoacetate	English
ACROS	English
SigmaAldrich	English
ALFA	English

Methyl diethylphosphonoacetate Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.

Methyl diethylphosphonoacetate Preparation Products And Raw materials

Raw materials	Acetic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, methyl ester-->Acetic acid, (diethoxyphosphino)-, methyl ester-->diethyl (2-chloro-2-oxoethyl)phosphonate-->tert-Butyl diethylphosphonoacetate-->DIETHYLPHOSPHONOACETIC ACID-->Diethyl methylphosphonate-->Methanol-->Ethanol-->Triethyl phosphite-->Methyl chloroacetate-->Methyl bromoacetate-->Triethyl phosphonoacetate
Preparation Products	METHYL TRANS-2-HEXENOATE, 98-->Methyl (2E)-3-(2-bromopyridin-3-yl)prop-2-enoate

Methyl Methyl glycolate TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE TRIETHYL 2-PHOSPHONOPENTANOATE DIISOPROPYL (ETHOXYCARBONYLMETHYL)PHOSPHONATE Tribenuron methyl TRIETHYL PHOSPHONOACETATE-2-13C tert-Butyl diethylphosphonoacetate Kresoxim-methyl Methyl bromoacetate Methyl methoxyacetate 2-ETHOXY-TRIETHYLPHOSPHONOACETATE Thiophanate-methyl TRIETHYL PHOSPHONOACETATE-1-13C TRIETHYL PHOSPHONOACETATE-13C2 METHYL Α-NAPHTHYLACETATE Triethyl 2-fluoro-2-phosphonoacetate Methyl diethylphosphonoacetate

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Methyl diethylphosphonoacetate

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