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| | 1,5-DIHYDROXYANTHRAQUINONE Basic information |
| Product Name: | 1,5-DIHYDROXYANTHRAQUINONE | | Synonyms: | 1,5-Dihydroxy-9,10-anthracenedione;1,5-Dihydroxy-9,10-anthraquinone;1,5-Dihydroxyanthra-9,10-quinone;1,5-Dihydroxyanthrachinon;1,5-dihydroxy-anthraquinon;Anthraquinone, 1,5-dihydroxy-;LABOTEST-BB LT00160027;1,5-DIHYDROXYANTHRAQUINONE | | CAS: | 117-12-4 | | MF: | C14H8O4 | | MW: | 240.21 | | EINECS: | 204-175-6 | | Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;Intermediates of Dyes and Pigments;Anthraquinones;Hydroxyanthraquinones | | Mol File: | 117-12-4.mol |  |
| | 1,5-DIHYDROXYANTHRAQUINONE Chemical Properties |
| Melting point | 279 °C (dec.)(lit.) | | Boiling point | 342.92°C (rough estimate) | | density | 1.56 g/cm3 | | vapor density | 8.3 (vs air) | | refractive index | 1.5430 (estimate) | | storage temp. | -20°C Freezer | | solubility | Poor solubility in all solvents tested.DMSO (Sparingly) | | form | Solid | | pka | 6.42±0.20(Predicted) | | color | Yellow to Green | | Merck | 14,689 | | BRN | 1881718 | | CAS DataBase Reference | 117-12-4(CAS DataBase Reference) | | EPA Substance Registry System | Anthrarufin (117-12-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36/37 | | WGK Germany | 3 | | RTECS | CB6630000 | | TSCA | Yes | | HS Code | 29146990 |
| | 1,5-DIHYDROXYANTHRAQUINONE Usage And Synthesis |
| Chemical Properties | Yellow to Green Solid | | Uses | Important intermediate in the manufacture of alizarin and indanthrene dyestuffs. Forms insoluble Ba and Ca lakes; has been proposed as analytical reagent for the detection of Ca. | | Uses | 1,5-Dihydroxyanthraquinone (anthrarufin) is an important intermediate for manufacturing disperse blue dyes. It is the key intermediates for manufacturing disperse blue dyes via dinitrodihydroxyanthraquinone and vat dyes via diaminoanthraquinones. | | Uses | 1,5-Dihydroxyanthraquinone is an anthraquinone derivative with suppressive effects against nitric oxide (NO) synthase. Potential antimalarial agent. Used in studies as a potential competitive non-peptidic inhibitor of HIV-1 protei nase.
| | Definition | ChEBI: A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 5. | | Purification Methods | Purify anthrarufin by column chromatography on silica gel with CHCl3/Et2O as eluent, followed by recrystallisation from acetone. Alternatively recrystallise it from glacial acetic acid [Flom & Barbara J Phys Chem 89 4489 1985]. [Beilstein 7 III 2359, 8 IV 3268.] |
| | 1,5-DIHYDROXYANTHRAQUINONE Preparation Products And Raw materials |
| Raw materials | Aluminium chloride hexahydrate-->Anthracene-->MERCURY(II) SULFATE-->1,4-Anthracenedione, 2,3-dihydro-5,9,10-trihydroxy--->1,8-Dihydroxyanthraquinone | | Preparation Products | Disperse Blue BGL-->CI 63010-->CI 63010-->1,2,5-TRIHYDROXYANTHRAQUINONE-->Solvent Blue 74-->1,5-dihydroxy-4,8-dinitro-9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid-->1,5-dichloro-4,8-dihydroxyanthraquinone |
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