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| | MRTX1133 Basic information |
| Product Name: | MRTX1133 | | Synonyms: | 2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-;MRTX1133;4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol;4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol;KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor | | CAS: | 2621928-55-8 | | MF: | C33H31F3N6O2 | | MW: | 600.63 | | EINECS: | | | Product Categories: | | | Mol File: | 2621928-55-8.mol |  |
| | MRTX1133 Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | solubility | DMSO:50.0(Max Conc. mg/mL);83.24(Max Conc. mM) | | form | A solid | | pka | 8.05±0.40(Predicted) |
| | MRTX1133 Usage And Synthesis |
| Uses | MRTX1133 is a potent and selective KRAS G12D inhibitor that targets KRAS G12D protein in both the active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, was able to bind to KRAS G12D protein in both active and inactive states, and selectively inhibited KRAS G12D-mutated cancer cells. In G12D mutant tumor models, it showed dose-dependent selective inhibition of the KRAS pathway and tumor regression. | | Chemical Properties | Solid powder. | | storage | Dry, dark and at 0-4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| | MRTX1133 Preparation Products And Raw materials |
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