2-(Trifluoromethyl)pyridine

2-(Trifluoromethyl)pyridine Basic information
Product Name:2-(Trifluoromethyl)pyridine
Synonyms:Pyridine, 2-(trifluoromethyl)-;ALPHA,ALPHA,ALPHA-TRIFLUORO-2-PICOLINE;à,à,à-trifluoro-2-picoline;α,α,α-trifluoro-2-picoline;2-(TRIFLUOROMETHYL)PYRIDINE;2-(Trifluoromethyl)pyridine,α,α,α-Trifluoro-2-picoline;2-trifluoromethylpyridine UNDRE RD;2-(CF3)-Pyridine
CAS:368-48-9
MF:C6H4F3N
MW:147.1
EINECS:626-032-0
Product Categories:Fluorine series;pharmacetical;Pyridines;Pyridine
Mol File:368-48-9.mol
2-(Trifluoromethyl)pyridine Structure
2-(Trifluoromethyl)pyridine Chemical Properties
Boiling point 139-141 °C
density 1.275 g/mL at 25 °C
refractive index n20/D 1.419
Fp 109 °F
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in most organic solvents.
pka0.60±0.12(Predicted)
form clear liquid
color Colorless to Light yellow
BRN 3112
InChIKeyATRQECRSCHYSNP-UHFFFAOYSA-N
CAS DataBase Reference368-48-9(CAS DataBase Reference)
NIST Chemistry Reference2-(CF3)-pyridine(368-48-9)
Safety Information
Hazard Codes Xi,F
Risk Statements 10-36/37/38
Safety Statements 16-26-36
RIDADR UN 1993 3/PG 3
WGK Germany 3
Hazard Note Flammable/Irritant
HazardClass 3
PackingGroup III
HS Code 2933399990
MSDS Information
ProviderLanguage
2-(Trifluoromethyl)pyridine English
SigmaAldrich English
ALFA English
2-(Trifluoromethyl)pyridine Usage And Synthesis
UsesLithiation with n-BuLi/LiOCH2CH2NMe2?takes place at the 6-position, affording access to 6-substituted derivatives. With LiTMP?. It is a building block in heterocycle synthesis.
Synthesis Reference(s)Synthesis, p. 932, 1980 DOI: 10.1055/s-1980-29276
2-(Trifluoromethyl)pyridine Preparation Products And Raw materials
Preparation Products2-(Trifluoromethyl)isonicotinic acid-->2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE-->6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione-->4-(Trifluoromethyl)pyridine-->2-Trifluoromethyl-6-pyridinecarboxylic acid
2,3,4,5-TETRAFLUORO-6-(TRIFLUOROMETHYL)PYRIDINE 4-CHLORO-6-METHYL-5-NITRO-2-(TRIFLUOROMETHYL)QUINOLINE 3-Trifluoromethylpyridine 7-CHLORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE 4-(Trifluoromethyl)pyridine 3-(Trifluoromethyl)benzaldehyde 2-(Trifluoromethyl)benzoic acid 4-Methylpyridine 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine Azamethiphos Trifluoromethyl 4-CHLORO-2,6-BIS(TRIFLUOROMETHYL)PYRIDINE 2,6-Lutidine 2,4,6-Collidine 3-BROMO-5-(TRIFLUOROMETHYL)PYRIDINE 2-(Trifluoromethyl)pyridine Pyridine 3-Aminobenzotrifluoride

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