ChemicalBook Product Catalog Chemical Reagents Organic reagents Guanidine salt ALEXIDINE DIHYDROCHLORIDE

ALEXIDINE DIHYDROCHLORIDE

ALEXIDINE DIHYDROCHLORIDE Basic information
Product Name:ALEXIDINE DIHYDROCHLORIDE
Synonyms:1,1'-HEXAMETHYLENE-BIS[5-(2-ETHYLHEXYL)BIGUANIDE];ALEXIDINE DIHYDROCHLORIDE;alexidine;Alexidine.2HCl;1,1'-Hexamethylene-bis[5-(2-ethylhexyl)biguanide] dihydrochloride;Prestwick_42;ALEXIDINE HYDROCHLORIDE;2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-
CAS:22573-93-9
MF:C26H56N10
MW:508.79
EINECS:245-096-7
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:22573-93-9.mol
ALEXIDINE DIHYDROCHLORIDE Structure
ALEXIDINE DIHYDROCHLORIDE Chemical Properties
Melting point 220-224
Boiling point 574.5±60.0 °C(Predicted)
density 1.10±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Methanol (Slightly)
pka12.34±0.10(Predicted)
form Solid
color White to Off-White
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
Hazard Note Irritant
HS Code 29224995
MSDS Information
ALEXIDINE DIHYDROCHLORIDE Usage And Synthesis
Chemical PropertiesWhite Powder with Light Yellow Cast
OriginatorAlexidine ,Science Lab.
UsesAlexidine Dihydrochloride has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.
DefinitionChEBI: An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.
Manufacturing ProcessA mixture of 16 g (0.09 mole) 1,1'-hexamethylene-bis(3-cyanoguanidine) and 20 d (0.12 mole) 2-ethylhexylamine hydrochloride is heated at 150-155°C for 3 hours. The mixture is cooled and the product is dissolved in 75 ml of hot water. The solution is treated with activated charcoal. 1,1'-Hexamethylene-bis- (5-(ethylhexyl)biguanide) is recrystalluized from methanol-ether, melting point 220.6-223.4°C.
Therapeutic FunctionAntiseptic
ALEXIDINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials2-ETHYLHEXYLAMINE HYDROCHLORIDE
Metformin IMINOCTADINE TRIS(ALBESILATE) BuforMin Hydrochloride Biguanide 1,6-HEXANEDIAMINE DIHYDROCHLORIDE 1-butylbiguanide ALEXIDINE DIHYDROCHLORIDE Poly(hexamethylenebiguanide)
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