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| | Meisoindigo Basic information |
| Product Name: | Meisoindigo | | Synonyms: | 1-METHYL-3,3'-BIINDOLE-2,2'(1H,1'H)-DIONE;3-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)-1,3-dihydro-1-methyl-2h-indol-2-one;MEISOINDIGO;N-methylisoindigotin;Dian III;Methylisoindigotin;Natura-α;Meisoindigo 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one | | CAS: | 97207-47-1 | | MF: | C17H12N2O2 | | MW: | 276.29 | | EINECS: | 200-256-5 | | Product Categories: | Inhibitors | | Mol File: | 97207-47-1.mol |  |
| | Meisoindigo Chemical Properties |
| Melting point | 236-237°C | | Boiling point | 482.0±45.0 °C(Predicted) | | density | 1.381±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic | | pka | 11.62±0.20(Predicted) | | form | powder to crystal | | color | Orange to Brown to Dark red |
| | Meisoindigo Usage And Synthesis |
| Description | Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner. | | Chemical Properties | mp 236-237°C | | Uses | Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy
| | Uses | Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs). | | references | [1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905. |
| | Meisoindigo Preparation Products And Raw materials |
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