1,1'-(Azodicarbonyl)-dipiperidine

1,1'-(Azodicarbonyl)-dipiperidine Basic information

Product Name:	1,1'-(Azodicarbonyl)-dipiperidine
Synonyms:	Diphenylpiperidylcarboxylate;AZODICARBOXYLIC ACID DIPIPERIDYL ESTER;Azodicarboxylic;diazenedicarboxylic acid bis(N,N-piperidide);1,1-IAZODICARBONYL)DIPIPERIDINE;Azodicarboxylic acid dipiperidine,95%;1,1'-(Azodicarbonyl);1,1'-(Azodicarbonyl)dipiperidine(ADDP)
CAS:	10465-81-3
MF:	C12H20N4O2
MW:	252.31
EINECS:
Product Categories:	API intermediates;Azodicarboxylates & Amides;Mitsunobu Reaction;Synthetic Organic Chemistry
Mol File:	10465-81-3.mol

1,1'-(Azodicarbonyl)-dipiperidine Chemical Properties

Melting point	132-136 °C(lit.)
Boiling point	366.4±25.0 °C(Predicted)
density	1.29±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	solid
pka	-0?+-.0.20(Predicted)
color	yellow
Water Solubility	Slightly soluble in water.
BRN	261917
InChI	InChI=1S/C12H20N4O2/c17-11(15-7-3-1-4-8-15)13-14-12(18)16-9-5-2-6-10-16/h1-10H2
InChIKey	OQJBFFCUFALWQL-UHFFFAOYSA-N
SMILES	N(C(N1CCCCC1)=O)=NC(N1CCCCC1)=O
CAS DataBase Reference	10465-81-3(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

1,1'-(Azodicarbonyl)-dipiperidine Usage And Synthesis

Description	1,1''-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound. It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.
Chemical Properties	yellow crystalline powder
Uses	It is used in a study of the copper-catalyzed addition of aryboronic acids to azodicarboxyl derivatives providing aryl-substituted hydrazides. It is widely used reagent for the Mitsunobu reaction. It is reactant for preparation of polyfluoroalkylated tripyrazolylmethane ligands, (-)-Hygromycin A via Mitsunobu glycosylation, optically active α,α-disubstituted amino acids via Mitsunobu reaction, aza-β-lactams through [2+2] cycloaddition reactions, glycosyl disulfides, pyridine ether PPAR agonists, S-glycosyl amino acid, building blocks for combinatorial neoglycopeptide synthesis and is a histamine H3 receptor antagonists. It is a reactant for Mitsunobu inversion reactions.

1,1'-(Azodicarbonyl)-dipiperidine Preparation Products And Raw materials

Raw materials

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