|
| | Trichloroethanol Basic information |
| Product Name: | Trichloroethanol | | Synonyms: | (Hydroxymethyl)trichloromethane;2,2,2-trichloro-ethano;2,2,2-Trichloroethyl alcohol;2,2,2-trichloroethylalcohol;beta,beta,.beta-Trichloroethanol;beta,beta,beta-trichloroethanol;Trichlorethanol;BETA,BETA,BETA-TRICHLOROETHYL ALCOHOL | | CAS: | 115-20-8 | | MF: | C2H3Cl3O | | MW: | 149.4 | | EINECS: | 204-071-0 | | Product Categories: | Miscellaneous;bc0001 | | Mol File: | 115-20-8.mol |  |
| | Trichloroethanol Chemical Properties |
| Melting point | 17.8 °C (lit.) | | Boiling point | 152-154 °C (lit.) | | density | 1.56 g/mL at 20 °C (lit.) | | vapor density | 5.16 (vs air) | | vapor pressure | 1 mm Hg ( 20 °C) | | refractive index | n20/D 1.49(lit.) | | Fp | >230 °F | | storage temp. | Store below +30°C. | | solubility | 83g/l | | form | Liquid | | pka | 12.24(at 25℃) | | color | Clear colorless to light yellow | | Specific Gravity | 1.560 (20/4℃) | | Odor | ethereal odor | | PH | 5-6 (H2O, 20℃)(saturated solution) | | Water Solubility | Slightly soluble in water. | | Sensitive | Hygroscopic | | Merck | 14,9638 | | BRN | 1697495 | | CAS DataBase Reference | 115-20-8(CAS DataBase Reference) | | NIST Chemistry Reference | Ethanol, 2,2,2-trichloro-(115-20-8) | | EPA Substance Registry System | 2,2,2-Trichloroethanol (115-20-8) |
| Hazard Codes | Xn | | Risk Statements | 22-41-67 | | Safety Statements | 26-39 | | RIDADR | 1760 | | WGK Germany | 1 | | RTECS | KM3850000 | | F | 3-21 | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29055910 | | Toxicity | LDLo orl-rat: 500 mg/kg CRAAA7 17,258,38 |
| | Trichloroethanol Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS TO LIGHT YELLOW LIQUID | | Uses | The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.
Some of its other application include:
- Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.
- Preparation of TCE ester of chlorosulfuric acid.
- Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.
| | Uses | Intermediate, anesthetic. | | Uses | 2,2,2-Trichloroethanol (TCE) is an active metabolite of Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] (T774055), a sedative/hypnotic that increases cerebral blood flow (CBF). | | Definition | ChEBI: 2,2,2-trichloroethanol is a chloroethanol. It has a role as a mouse metabolite. | | Safety Profile | Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andrectal routes. Human mutation data reported. Explosivereaction with concentrated sodium hydroxide solutions.When heated to decomposition it emits toxic fumes ofClí. Us |
| | Trichloroethanol Preparation Products And Raw materials |
|
