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| | (1R)-(-)-Menthyl acetate Basic information |
| Product Name: | (1R)-(-)-Menthyl acetate | | Synonyms: | 2-isopropyl-5-methyl-,acetate,l-cyclohexan-1-o;5-methyl-2-(1-methylethyl)-,acetate,[1R-(1.alpha.,2.beta.,5.alpha.)]-Cyclohexanol;acetate,(1r,3r,4s)-(-)-mentho;MENTHYL ACETATE, L-;L-MENTHYL ACETATE;FEMA 2668;(-)-ACETOXY-P-MENTHANE;(-)-(1R)-MENTHYL ACETATE | | CAS: | 2623-23-6 | | MF: | C12H22O2 | | MW: | 198.3 | | EINECS: | 220-076-0 | | Product Categories: | Pharmaceutical Raw Materials;Esters;Chiral Building Blocks;EstersAlphabetic;M;MEA - MES;Monocyclic Monoterpenes;Biochemistry;Terpenes;Organic Building Blocks | | Mol File: | 2623-23-6.mol |  |
| | (1R)-(-)-Menthyl acetate Chemical Properties |
| Melting point | <25 °C | | alpha | -81°(20/D, c=8, C6H6) | | Boiling point | 229-230 °C(lit.) | | density | 0.92 g/mL at 25 °C(lit.) | | vapor pressure | 45Pa at 20℃ | | FEMA | 2668 | MENTHYL ACETATE (ISOMER UNSPECIFIED) | | refractive index | n20/D 1.447(lit.) | | Fp | 171 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | neat | | Specific Gravity | 0.922 | | color | Colourless | | Odor | at 100.00 %. mentholic minty herbal tea fruity woody floral earthy | | Odor Type | mentholic | | optical activity | [α]20/D 81°, c = 8 in benzene | | Water Solubility | 23.2mg/L at 20℃ | | JECFA Number | 431 | | Merck | 14,5839 | | BRN | 2208505 | | LogP | 4.39 at 25℃ | | CAS DataBase Reference | 2623-23-6(CAS DataBase Reference) | | EPA Substance Registry System | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1R,2S,5R)- (2623-23-6) |
| Safety Statements | 24/25 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 3 | | RTECS | AI5900000 | | TSCA | Yes | | HS Code | 2915 39 00 | | Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
| | (1R)-(-)-Menthyl acetate Usage And Synthesis |
| Chemical Properties | (1R)-(-)-Menthyl acetate occurs in peppermint oils. It is a colorless liquid with a fresh, fruity,
peppermint odor.
(?)-Menthyl acetate is prepared by acetylation of (?)-menthol (e.g., with acetic
anhydride). It is used mainly in peppermint flavors and reconstituted peppermint
oils, but also to a small extent in perfumery. | | Uses | L-Menthyl Acetate, and its derivatives, is used as a penetration enhancers, to enhance the skin permeation of various drugs with differing lipophilicities, such as 5-aminolevulinic acid (ALA), 5-fluorouracil (5-FU), isosorbide dinitrate (ISDN), lidocaine (LD), etc. | | Definition | ChEBI: (-)-Menthyl acetate is a p-menthane monoterpenoid. | | Flammability and Explosibility | Notclassified | | Biochem/physiol Actions | Taste at 25 ppm | | Safety Profile | Low toxicity by
ingestion and skin contact. A skin irritant.
When heated to decomposition it emits
acrid smoke and irritating fumes. |
| | (1R)-(-)-Menthyl acetate Preparation Products And Raw materials |
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