ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Amino alcohol derivative L-Phenylglycinol

L-Phenylglycinol

L-Phenylglycinol Basic information
Product Name:L-Phenylglycinol
Synonyms:((1S)-1-HydroxyMethyl-2-phenylethyl)aMine;(2S)-2-AMino-3-phenyl-1-propanol;(S)-(-)-2-AMino-3-phenyl-1-glycinol;(S)-2-AMino-1-hydroxy-3-phenylpropane;(βS)-β-AMino-benzenepropanol;(S)-(-)-2-AMINO-3-PHENYL-1-PROPANOL FOR;(S)-3-Phenyl-2-aMino-1-propanol;1-Propanol, 2-aMino-3-phenyl-, L- (8CI)
CAS:3182-95-4
MF:C9H13NO
MW:151.21
EINECS:221-674-4
Product Categories:Chiral Reagents;Intermediates & Fine Chemicals;chiral;Chiral Reagent;Pharmaceuticals;Intermediates;Pharmaceutical Intermediates;Amino Alcohols;Phenylalanine [Phe, F];Amino Alcohols (Chiral);Chiral Building Blocks;for Resolution of Acids;Benzene derivatives;Amino Acids & Derivatives;Optical Resolution;Synthetic Organic Chemistry;Amino alcohols
Mol File:3182-95-4.mol
L-Phenylglycinol Structure
L-Phenylglycinol Chemical Properties
Melting point 92-94 °C(lit.)
alpha -23 º (c=5,EtOH)
Boiling point 273.23°C (rough estimate)
density 1.0406 (rough estimate)
refractive index -24.5 ° (C=5, EtOH)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in chloroform, ethyl acetate, ethanol and methanol.
pka12.85±0.10(Predicted)
form Crystalline Powder
color White to light yellow
optical activity[α]22/D 22.8°, c = 1.2 in 1 M HCl
Sensitive Air Sensitive
BRN 2208238
InChIKeySTVVMTBJNDTZBF-VIFPVBQESA-N
CAS DataBase Reference3182-95-4(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45-24/25-27
RIDADR UN 3259 8/PG 3
WGK Germany 3
RTECS UA6900000
F 10-23
HazardClass 8
PackingGroup Ⅲ
HS Code 29221980
MSDS Information
ProviderLanguage
L(-)-2-Amino-3-phenyl-1-propanol English
SigmaAldrich English
ACROS English
ALFA English
L-Phenylglycinol Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powder
UsesEnantiomer of L-Phenylalaninol, an inhibitor of intestinal Phenylalanine absorption.
UsesInhibits the intestinal absorption of Phenylalanine, making it a prospective treatment for phenylketonuria.
Usesantiulcer
DefinitionChEBI: L-phenylalaninol is an amino alcohol resulting from the formal reduction of the carboxy group of L-phenylalanine to the corresponding alcohol. It is a member of amphetamines, an amino alcohol, a primary amino compound and a primary alcohol.
General Description(S)-(-)-2-Amino-3-phenyl-1-propanol is a chiral amino alcohol.
Purification MethodsIt can be recrystallised from Et2O, *C6H6/pet ether (b 40-60o) or toluene and distilled in a vacuum. It has been purified by dissolving in Et2O, drying over K2CO3, filtering, evaporating to a small volume, cooling in ice and collecting the plates. Store them in the presence of KOH (i.e. CO2—free atm). [Karrer & Ehrhardt Helv Chim Acta 34 3203 1951, Oeda Bull Chem Soc Jpn 13 465 1938.] The picrate has m 141-141.5o (from EtOH/pet ether). The hydrogen oxalate has m 177o, 161-162o [Hunt & McHale J Chem Soc 2073 1957]. The racemate has m 87-88o from *C6H6/pet ether (75-77o from Et2O), and the hydrochloride has m 139-141o [Fodor et al. J Chem Soc 1858 1951]. [Beilstein 13 IV 1920.]
L-Phenylglycinol Preparation Products And Raw materials
Preparation Products(S)-2-Benzylamino-3-phenyl-1-propanol-->N-Boc-L-Phenylalaninol-->2,6-Bis[(4S)-benzyl-2-oxazolin-2-yl]pyridine-->(S)-4-BENZYL-1,3-THIAZOLIDINE-2-THIONE-->TMC-58B-->(S)-(+)-2-DIBENZYLAMINO-3-PHENYL-1-PROPANOL-->Acetamide, 2-chloro-N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-
Phenprobamate Ketorolac tromethamine AMINOPROPANOL PHENYL RESIN ALTRENOGEST 6-Aminocaproic acid Glycine PHENYL VALERATE L-Phenylglycinol (S)-(-)-2-Methyl-1-butanol Tris(hydroxymethyl)aminomethane AMINO ACIDS 3-Aminophenol TRISTEARIN Fosfomycin tromethamine (±)-α-Phenylglycino Phenylacetic acid 1-Propanol
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