ChemicalBook Product Catalog Organic Chemistry Phosphines Ethyl diethoxyphosphinylformate

Ethyl diethoxyphosphinylformate

Ethyl diethoxyphosphinylformate Basic information
Product Name:Ethyl diethoxyphosphinylformate
Synonyms:Diethyl carbethoxyphosphonate;Diethyl ethoxycarbonylphosphonate;Ethyl diethoxyphosphinecarboxylate oxide;Formic acid, phosphono-, triethyl ester;phosphinecarboxylicacid,diethoxy-,ethylester,oxide;Triethyl carboxyphosphonate;Triethyl phosphonomethanoate;(ETHOXYCARBONYL)PHOSPHONIC ACID DIETHYL ESTER
CAS:1474-78-8
MF:C7H15O5P
MW:210.16
EINECS:216-016-8
Product Categories:Organic Building Blocks;Phosphonates/Phosphinates;Phosphorus Compounds
Mol File:1474-78-8.mol
Ethyl diethoxyphosphinylformate Structure
Ethyl diethoxyphosphinylformate Chemical Properties
Boiling point 135 °C12 mm Hg(lit.)
density 1.11 g/mL at 25 °C(lit.)
refractive index n20/D 1.423(lit.)
Fp >230 °F
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Methanol (Slightly)
form neat
Specific Gravity1.11
color Colorless to Almost colorless
BRN 1781949
Stability:Moisture Sensitive
CAS DataBase Reference1474-78-8(CAS DataBase Reference)
NIST Chemistry ReferencePhosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)
EPA Substance Registry SystemPhosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-43
Safety Statements 24/25-36/37-26-37-24
WGK Germany 3
TSCA Yes
HS Code 2931 39 90
MSDS Information
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Ethyl diethoxyphosphinylformate English
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ACROS English
ALFA English
Ethyl diethoxyphosphinylformate Usage And Synthesis
Chemical PropertiesClear colorless to slightly yellow liquid
UsesDiethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.
General Descriptionfor synthesis
Purification MethodsDissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]
Ethyl diethoxyphosphinylformate Preparation Products And Raw materials
Preparation ProductsFoscarnet sodium-->Foscarnet Impurity A
Tripropyl orthoformate Dimethyl hydroxymethylphosphonate TRIMETHYL PHOSPHONOFORMATE PhosphonoMethanol ETHYL METHYLPHOSPHINATE METHOXY CARBONYL PHOSPHONIC ACID Foscarnet Diethyl (hydroxymethyl)phosphonate ETHYL METHYLPHOSPHONIC ACID Ethyl diethoxyphosphinylformate METHYLPHOSPHONIC ACID Methyldiethoxyphosphine Dimethyl methylphosphonate Diethyl methylphosphonate METHYL METHYLPHOSPHONIC ACID
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