ChemicalBook Product Catalog Biochemical Engineering Chinese Herbs 10-Gingerol

10-Gingerol

10-Gingerol Basic information
Product Name:10-Gingerol
Synonyms:10-GINGEROL, HPLC 98%;10-GINGEROL;5-HYDROXY-1-(4-HYDROXY-3-METHOXYPHENYL)-3-TETRADECANONE;(5S)-1-(3-Methoxy-4-hydroxyphenyl)-5-hydroxytetradecane-3-one;(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone;(S)-1-(3-Methoxy-4-hydroxyphenyl)-5-hydroxytetradecane-3-one;(S)-12-Oxo-14-(3-methoxy-4-hydroxyphenyl)tetradecane-10-ol;(5S)-5-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)tetradecan-3-one
CAS:23513-15-7
MF:C21H34O4
MW:350.49
EINECS:
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;The group of Ginerols;Miscellaneous Natural Products
Mol File:23513-15-7.mol
10-Gingerol Structure
10-Gingerol Chemical Properties
Melting point 56-58 °C
Boiling point 499.7±35.0 °C(Predicted)
density 1.037±0.06 g/cm3(Predicted)
Fp 166℃
storage temp. 2-8°C
solubility methanol: soluble5mg/mL, clear, colorless
form neat
pka10.02±0.20(Predicted)
color Yellow
Water Solubility practically insoluble in water
InChIKeyAIULWNKTYPZYAN-SFHVURJKSA-N
LogP4.900 (est)
Safety Information
Risk Statements 53
Safety Statements 24/25
WGK Germany 3
HS Code 29145019
MSDS Information
10-Gingerol Usage And Synthesis
Description10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH , superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; ) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against M. avium and M. tuberculosis (MICs = 25 and 50 μg/ml, respectively). 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.
Uses(+)-(S)-[10]-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.
DefinitionChEBI: (10)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene.
Biochem/physiol Actions[10]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity.
10-Gingerol Preparation Products And Raw materials
8-PARADOL 8-GINGEROL Phenylfluorone 3-TETRADECANONE DIPHENYLCYCLOPROPENONE 6-Gingerol 4-Methoxyphenylacetone 6-GINGEROL,(+/-) Benzoylcyclohexane 4-tetradecylphenol 10-Gingerol 4'-Hydroxyacetophenone GINGEROL, 10-(P) 2'-Hydroxyacetophenone CHLOROPHOSPHONAZO III Vanillylacetone Diphenylsilanediol Diacetone Alcohol
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