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N-Benzyloxycarbonyl-D-proline

N-Benzyloxycarbonyl-D-proline Basic information
Product Name:N-Benzyloxycarbonyl-D-proline
Synonyms:Cbz-D-Pro;PROLINA-Z-D;1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL)ESTER, (2R)-;1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (R)-;1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID;(R)-Z-pyrrolidine-2-carboxylic acid;Z-D-proline≥ 98% (HPLC);BENZYLOXYCARBONYL-D-PROLINE
CAS:6404-31-5
MF:C13H15NO4
MW:249.26
EINECS:229-021-5
Product Categories:Amino Acids;Amino Acids (N-Protected);Proline [Pro, P];Biochemistry;Cbz-Amino Acids;Cbz-Amino acid series;Z-Amino Acids and Derivatives;Amino Acid Derivatives;Peptide Synthesis;Proline
Mol File:6404-31-5.mol
N-Benzyloxycarbonyl-D-proline Structure
N-Benzyloxycarbonyl-D-proline Chemical Properties
Melting point 76-78 °C(lit.)
alpha 40 º (c=2, EtOH)
Boiling point 432.3±45.0 °C(Predicted)
density 1.309±0.06 g/cm3(Predicted)
refractive index 40 ° (C=2, EtOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka3.99±0.20(Predicted)
form Crystalline Powder or Powder
color White
optical activity[α]25/D +40.2°, c = 2 in ethanol
BRN 485188
InChIKeyJXGVXCZADZNAMJ-LLVKDONJSA-N
CAS DataBase Reference6404-31-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 24/25
WGK Germany 3
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
N-Benzyloxycarbonyl-D-proline Usage And Synthesis
Chemical PropertiesWhite crystalline powder or powder
UsesN-(Benzyloxycarbonyl)-D-proline is an an N-Cbz-protected form of D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
N-Benzyloxycarbonyl-D-proline Preparation Products And Raw materials
Preparation Products(R)-5-BROMO-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-1H-INDOLE-->(2R)-N-Methyl-2-PyrrolidinecarboxaMide
N-alpha-Benzyloxycarbonyl-D-proline succinimidyl ester,BENZYLOXYCARBONYL-D-PROLINE N-HYDROXYSUCCINIMIDE ESTER Z-D-PYR-OH N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER (2R)-1-[(benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid Hyaluronic acid Ethyl 2-(Chlorosulfonyl)acetate Trimethoprim PYRAZOPHOS 2-[(BENZYLOXY)CARBONYL]-4-(TRIFLUOROMETHYL)-2-AZABICYCLO[2.1.1]HEXANE-1-CARBOXYLIC ACID Folic acid L-Proline N-Benzyloxycarbonyl-D-proline N-(F13 CBZ) D-PROLINE N-CBZ-4-OXO-D-PROLINE CARBOXYLIC ACID L-PROLINE-(4-3H(N)) AKOS 334 (2R, 4R)-4-(TOLUENE-4-SULFONYLOXY)-1-[BENZYLOXYCARBONYL]-PYRROLIDINE-2-ETHYLCARBOXYLATE
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