|
| | (S)-Ketorolac Basic information |
| | (S)-Ketorolac Chemical Properties |
| Melting point | 160-167?C | | Boiling point | 493.2±40.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly | | form | A crystalline solid | | pka | 4.29±0.20(Predicted) |
| | (S)-Ketorolac Usage And Synthesis |
| Description | (S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation. | | Chemical Properties | Off-White Solid | | Uses | (S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory. | | Uses | The R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory. | | Definition | ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s
mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. |
| | (S)-Ketorolac Preparation Products And Raw materials |
|
