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| | DASA-58 Basic information |
| Product Name: | DASA-58 | | Synonyms: | DASA-58;3-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]benzenamine;DASA58; DASA 58;CS-1563;Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-;DASA58,inhibit,Inhibitor,DASA 58,DASA-58,glycolysis,TXNIP,cancer metabolism,Pyruvate Kinase,pyruvate kinase M2,breast cancer,AMPK | | CAS: | 1203494-49-8 | | MF: | C19H23N3O6S2 | | MW: | 453.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1203494-49-8.mol |  |
| | DASA-58 Chemical Properties |
| Boiling point | 681.5±65.0 °C(Predicted) | | density | 1.453±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | insoluble in EtOH; insoluble in H2O; ≥127.2 mg/mL in DMSO | | form | solid | | pka | 3.35±0.10(Predicted) |
| | DASA-58 Usage And Synthesis |
| Description | DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 μM in cells). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β. It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice. | | Definition | ChEBI: 3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl]aniline is a member of benzenes and a sulfonamide. | | references | [1]. anastasiou d, yu y, israelsen wj, et al. pyruvate kinase m2 activators promote tetramer formation and suppress tumorigenesis. nature chemical biology, 2012, 8(10): 839-847. |
| | DASA-58 Preparation Products And Raw materials |
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