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| | Vonoprazan FuMarate Basic information |
| Product Name: | Vonoprazan FuMarate | | Synonyms: | Vonoprazan FuMarate###NA;1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate;Vonoprazan-025-Salt1;Voranomazin;Vonoprazan FuMarate USP/EP/BP;Vonoprazan fumarate,TAK-438,Takecab;Vonoprazan fumarate 13C D3;Fumarate vonorazan | | CAS: | 881681-01-2 | | MF: | C21H20FN3O6S | | MW: | 461.46 | | EINECS: | 1592732-453-0 | | Product Categories: | | | Mol File: | 881681-01-2.mol |  |
| | Vonoprazan FuMarate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 50 mg/mL (108.35 mM) | | form | Solid | | color | White to Off-White |
| | Vonoprazan FuMarate Usage And Synthesis |
| Uses | Vonoprazan Fumarate (CAS# 881681-01-2) is a useful research chemical and a ATPase potassium-competitive acid blocker. | | benefits | Compared with traditional irreversible proton pump inhibitors (such as omeprazole, esomeprazole, etc.), Vonoprazan fumarate advantages:
① The onset of action is good, and the maximum acid-suppressing effect will be achieved on the first day of administration;
② Oral administration, not affected by gastric acid damage;
③It can improve the phenomenon of acid breakthrough at night. | | General Description | Vonoprazan fumarate (TAK-438) is a new oral anti-gastric acid drug jointly launched by Takeda Pharmaceutical and Otsuka Pharmaceutical. It can be used for the treatment of erosive esophagitis, gastric ulcer and duodenal ulcer. | | Mechanism of action | Vonoprazan fumarate is a potassium ion (K+) competitive acid blocker (P-CAB), which is a reversible proton pump inhibitor. It can inhibit the combination of K+ and H+-K+-ATPase (proton pump), so that secretion of gastric acid is terminated. Vonoprazan fumarate has a strong and lasting inhibitory effect on gastric acid secretion. |
| | Vonoprazan FuMarate Preparation Products And Raw materials |
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