2-(Trimethylsilyl)thiazole

2-(Trimethylsilyl)thiazole Basic information

Product Name:	2-(Trimethylsilyl)thiazole
Synonyms:	2-TST;2-THIAZOLYTRIMETHYLSILANE;2-Thiazolyltrimethylsilane;Thiazole, 2-(trimethylsilyl)-;2-（trimethyl)thiazole;2-TRIMETHYLSILYTHIAZOLE;Dondoni;2-Thiazolyltrimethylsilane, 2-TST
CAS:	79265-30-8
MF:	C6H11NSSi
MW:	157.31
EINECS:
Product Categories:	Thiazoles, Isothiazoles & Benzothiazoles;API intermediates;Si (Classes of Silicon Compounds);Si-(C)4 Compounds;Silicon Compounds (for Synthesis);Synthetic Organic Chemistry;Thiazoles, Isothiazoles &Benzothiazoles;Building Blocks;C3 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Thiazoles
Mol File:	79265-30-8.mol

2-(Trimethylsilyl)thiazole Chemical Properties

Boiling point	56-57 °C10 mm Hg(lit.)
density	0.985 g/mL at 25 °C(lit.)
refractive index	n20/D 1.497(lit.)
Fp	135 °F
storage temp.	Inert atmosphere,2-8°C
solubility	THF: very soluble(lit.)
pka	2.91±0.10(Predicted)
form	Liquid
color	Clear colorless to slightly yellow
Specific Gravity	0.99
Water Solubility	IMMISCIBLE
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	3538017
CAS DataBase Reference	79265-30-8(CAS DataBase Reference)

Safety Information

MSDS Information

2-(Trimethylsilyl)thiazole Usage And Synthesis

Chemical Properties	Colorless to light yellow liqui
Physical properties	bp 51–53 °C/10 mmHg; d 0.992 g mL?1; nD 1.4980.
Uses	2-(Trimethylsilyl)thiazole is used as formyl anion equivalent; effective one-carbon homologating reagent of alkoxy aldehydes, amino aldehydes, and dialdoses.It takes part in the reactions of Homologation of Aldehydes, Metalation and Reactivity with Electrophiles, Cross-coupling Reactions, etc.
Preparation	Although 2-(trimethylsilyl)thiazole (1) is commercially available, it can be easily prepared on a multigram scale from 2-bromothiazole, n-butyllithium, and chlorotrimethylsilane as shown in eq 1.

2-(Trimethylsilyl)thiazole Preparation Products And Raw materials

Preparation Products

Login