ChemicalBook Product Catalog Organic Chemistry Heterocyclic Compounds 6-Aminoindazole

6-Aminoindazole

6-Aminoindazole Basic information
Product Name:6-Aminoindazole
Synonyms:LABOTEST-BB LT00114795;6-AMINOBENZOPYRAZOLE;6-AMINOINDAZOLE;AKOS BBS-00003578;6-Aminoidazole;Aminoidazole;indazol-6-ylamine;Aminoindazole
CAS:6967-12-0
MF:C7H7N3
MW:133.15
EINECS:230-177-1
Product Categories:Building Blocks;Heterocyclic Building Blocks;pharmacetical;Indazoles;Amines and Anilines;Heterocycles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Intermediate
Mol File:6967-12-0.mol
6-Aminoindazole Structure
6-Aminoindazole Chemical Properties
Melting point 204-206 °C (dec.) (lit.)
Boiling point 376.6±15.0 °C(Predicted)
density 1.367±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka15.61±0.40(Predicted)
form Powder
color Tan
InChIKeyKEJFADGISRFLFO-UHFFFAOYSA-N
CAS DataBase Reference6967-12-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26
WGK Germany 3
RTECS NK7712000
HS Code 29339980
MSDS Information
ProviderLanguage
6-Aminoindazole English
SigmaAldrich English
6-Aminoindazole Usage And Synthesis
Description6-Aminoindazole is a tetronic acid derivative that has been shown to have an inhibitory effect on the activity of cyclopentyl and ethylene diamine. This drug also increases blood pressure in animals, and is found to be a potent inhibitor of thrombin receptor.
Chemical Propertieslight brown powder
Application6-Aminoindazole is structurally similar to quinoline derivatives and has been shown to have anticancer activity in human ovarian carcinoma cells. The affinity constants for this compound are higher than those for most other compounds with anti-cancer effects, which may be due to the presence of hydrogen bonds between the nitrogen atoms and the carbonyl group.
DefinitionChEBI: 1H-indazol-6-amine is a member of indazoles.
Purification MethodsIt is recrystallised from H2O or EtOH and sublimes in a vacuum. [Beilstein 25 H 317.]
6-Aminoindazole Preparation Products And Raw materials
Preparation Products6-IODO (1H)INDAZOLE-->Axitinib Impurity B-->BenzaMide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-Methyl--->6-Hydroxyindazole-->1H-indazole-6-sulfonyl chloride(WXC09037)-->N-(1H-INDAZOL-6-YL)THIOUREA-->6-(Piperazin-1-yl)-1H-indazole
5,6-DINITROINDAZOLE 3-CHLORO-6-NITRO (1H)INDAZOLE 4,6-DINITRO-1H-INDAZOLE 2-((1H-INDAZOL-6-YLAMINO)METHYLENE)INDANE-1,3-DIONE 2-CHLORO-N-(1H-INDAZOL-6-YL)-ACETAMIDE 4-CHLORO-6-AMINOINDAZOLE-3-CARBOXYALDEHYDE 6-SULFANILAMIDOINDAZOLE 2-METHYL-4,6-DINITRO-2H-INDAZOLE 5-AMINOINDAZOLE-3-CARBOXYLIC ACID 1-(4-METHOXY-PHENYL)-6-NITRO-1H-INDAZOLE 6-NITRO-1-PHENYL-1H-INDAZOLE 5-23-06-00185 (Beilstein Handbook Reference) 6-Aminoindazole SALICYLIDENE-6-AMINOINDAZOLE 6-Nitroindazole 1-METHYL-1H-INDAZOL-6-YLAMINE 1H-Indazol-6-amine, dihydriodide 5,6-DIAMINOINDAZOLE
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