ChemicalBook Product Catalog Organic Chemistry Amides Naphthenic amines derivatives 2-Iodoaniline

2-Iodoaniline

2-Iodoaniline Basic information
Product Name:2-Iodoaniline
Synonyms:LABOTEST-BB LTBB000671;BENZENAMINE, 2-IODO-;2-Iodoaniline o-Iodoaniline;2-IODOANILINE 98%;2-Iodoaniline, 98+%;1-Amino-2-iodobenzene;2-Iodoaniline, 98% 25GR;2-Iodoaniline, 98% 5GR
CAS:615-43-0
MF:C6H6IN
MW:219.02
EINECS:210-426-0
Product Categories:Anilines, Aromatic Amines and Nitro Compounds;Amines;Phenyls & Phenyl-Het;Anilines, Amides & Amines;Iodine Compounds;Phenyls & Phenyl-Het;C2 to C6;Nitrogen Compounds;Pharmaceutical Intermediates;bc0001
Mol File:615-43-0.mol
2-Iodoaniline Structure
2-Iodoaniline Chemical Properties
Melting point 55-58 °C (lit.)
Boiling point 262.0±23.0 °C(Predicted)
density 1.8155 (estimate)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Chloroform, DCM, Ethyl Acetate, Toluene
form Crystalline Needles
pka2.6(at 25℃)
color Yellow to brown
Water Solubility Insoluble in water.
Sensitive Light Sensitive
BRN 2204899
InChIKeyUBPDKIDWEADHPP-UHFFFAOYSA-N
CAS DataBase Reference615-43-0(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenamine, 2-iodo-(615-43-0)
EPA Substance Registry Systemo-Iodoaniline (615-43-0)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 20/21/22-37/38-36/37/38
Safety Statements 36/37-36/37/39-26-36
RIDADR 2811
WGK Germany 3
F 8
Hazard Note Irritant
TSCA T
HazardClass 6.1(b)
PackingGroup III
HS Code 29214210
MSDS Information
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2-Iodoaniline English
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2-Iodoaniline Usage And Synthesis
Chemical PropertiesYELLOW TO BROWN CRYSTALLINE NEEDLES
Uses2-Iodobenzenamine is an synthetic intermediate for the synthesis of complex organic compounds and pharmaceuticals.
Uses2-Iodoaniline is used as an intermediate in organic synthesis.
Preparation2-iodoaniline and its derivatives are commonly used for the preparation of indole-based anticancer drugs, which have high market value, and further synthesis can lead to high-end synthetic intermediates with complex structures.
Take a reaction tube, add 50mg of sodium azide, 75mg of 1-(2-iodophenyl)ethanol, 300uL of trifluoroacetic acid, 150uL of methanesulfonic acid and 1.0mL of hexane, and stir for 24 hours at 40℃. After the reaction, 10 mL of sodium hydroxide solution was added to quench the reaction. The organic phase was washed with 5 mL of brine, and the organic phase was combined and separated by column chromatography to obtain 58.4 mg of 2-iodoaniline in 89% yield.
Synthesis of 2-iodoaniline
Synthesis of 2-iodoaniline
Purification MethodsDistil 2-iodoaniline with steam and crystallise it from *benzene/pet ether. The N-acetyl derivative has m 110o. [Beilstein 12 IV 1542.]
2-Iodoaniline Preparation Products And Raw materials
Preparation Products5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one-->1-Iodo-2-nitrobenzene-->1-Fluoro-2-iodobenzene-->2-Aminobiphenyl-->2-NITRO-6(5H)-PHENANTHRIDINONE-->2-(Phenylthio)aniline-->2-Iodobiphenyl-->2-Aminodiphenylamine-->1,2-Diiodobenzene-->2-(2-AMINOPHENYL)BENZOTHIAZOLE 97-->BENTRANIL-->2-TERT-BUTYL-1H-INDOLE-->5,10-DIHYDRO-PHENAZINE-->2-Methoxyquinoline
N-[(2-chlorophenyl)methyl]-2-iodoaniline N-[(2-chlorophenyl)methyl]-3-iodoaniline 2-BENZOYLACETANILIDE N-[(2-bromophenyl)methyl]-3-iodoaniline N-[(3,4-difluorophenyl)methyl]-2-iodoaniline 4-AMINO-3,5-DIIODOBENZOIC ACID METHYL ESTER EMERALDINE BASE POLYANILINE N-[(2,6-dichlorophenyl)methyl]-4-iodoaniline N-[(2,6-difluorophenyl)methyl]-2-iodoaniline N-[(3,4-dimethoxyphenyl)methyl]-3-iodoaniline Acetrizoic acid 2,6-DIIODO-4-NITROANILINE ALTRENOGEST ETHYL 4-AMINO-3,5-DIIODOBENZOATE p-iodophenylurethane 2-Bromo-4-iodoaniline N-[(3-bromo-4-fluorophenyl)methyl]-2-iodoaniline AMINO ACIDS
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