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| | Coumarin 120 Basic information |
| Product Name: | Coumarin 120 | | Synonyms: | 7-Amino-4-methyl-2H-chromen-2-one, 7-Amino-4-methyl-2-oxo-2H-chromene, 7-Amino-4-methyl-2-oxo-2H-1-benzopyran;Coumarin 120, AMC;(2S,5R,6R)-6-[(2R)-2-aMino-2-(4-hydroxyphenyl)acetaMido]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;7-AMino-4-MethylcouMarin ;7-AMino-4-MethylcouMarin, pure, 98% 1GR;7-AMino-4-MethylcouMarin 99%;7-Amino-4-methylcoumarin≥ 98% (HPLC);AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2* | | CAS: | 26093-31-2 | | MF: | C10H9NO2 | | MW: | 175.18 | | EINECS: | 247-454-8 | | Product Categories: | Building block;Peptide;Coumarins;Other Reagents;Labeling and Diagnostics Reagents | | Mol File: | 26093-31-2.mol |  |
| | Coumarin 120 Chemical Properties |
| Melting point | 223-226 °C (lit.) | | Boiling point | 306.47°C (rough estimate) | | density | 1.1999 (rough estimate) | | refractive index | 1.5060 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide. | | pka | 1.89 ± 0.20, most basic, temperature:
25 °C | | form | Crystalline Powder | | color | Beige to brown | | λmax | 351 nm (MeOH); 342 nm (Buffer
pH 7) | | Sensitive | Light Sensitive | | BRN | 142231 | | Biological Applications | Identifyingbacteria; measuring urinary kallikrein levels;monitoring platinum(iv) reduction and platinum(ii)reactions in cancer cells; as a substrate for measuringadipinylamidases activity, aromatic amino aciddecarboxylases activity, histone deacetylasesactivity, hydrolases/esterases activity,β-lactamases activity, microbial nitroreductasesactivity, penicillin G acylases activity,proteases/proteinases/peptidases activity,glutamyltransferases activity, tryptophanasesactivity; as an effective antitubercular agent; use astemperature sensor, | | Major Application | For authentification; dyelasers; color display devices; inks;monitoring underlying corrosion on coated aluminum;photoinitiating systems; recording materials;semiconductor devices; dye-sensitized solar cells(DSCs); mesoporous silica fibers; SiO2 sonogelhybrid materials; textiles; waveguides;whitening agents, | | InChIKey | GLNDAGDHSLMOKX-UHFFFAOYSA-N | | CAS DataBase Reference | 26093-31-2(CAS DataBase Reference) | | NIST Chemistry Reference | Coumarin, 7-amino-4-methyl-(26093-31-2) | | EPA Substance Registry System | 2H-1-Benzopyran-2-one, 7-amino-4-methyl- (26093-31-2) |
| | Coumarin 120 Usage And Synthesis |
| Chemical Properties | Coumarin 120 is Light yellow beige powder
| | Uses | Coumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.
| | Uses | suitable for determining polygalacturonase activity | | Uses | λ max 354 nm in EthanolSuitable as laser dye and used as a fluorescent labeling reagent for trace determination of enzymes. | | Definition | ChEBI: Coumarin 120 is a member of 7-aminocoumarins. It has a role as a fluorochrome. | | General Description | 7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O. | | Biochem/physiol Actions | 7-Amino-4-methylcoumarin is a coumarin derivative, which serves as a fluorescence reference standard to screen protease inhibitors. | | storage | +4°C | | Purification Methods | Dissolve it in 5% HCl, filter and basify with 2M ammonia. The precipitate is dried in a vacuum and recrystallised from dilute EtOH. It yields a blue solution and is light sensitive. [Sigler Synthesis 614 1980, Kanaoka et al. Chem Pharm Bull Jpn 30 1485 1982, Beilstein 18/11 V 445.] |
| | Coumarin 120 Preparation Products And Raw materials |
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