ChemicalBook Product Catalog Chemical Reagents Organic reagents Amide 4'-CHLOROACETANILIDE

4'-CHLOROACETANILIDE

4'-CHLOROACETANILIDE Basic information
Product Name:4'-CHLOROACETANILIDE
Synonyms:ACETIC ACID 4-CHLOROANILIDE;ACETAMINOPHEN IMPURITY J;ACETAMINOPHENE IMP J;4'-CHLOROACETANILIDE;4-CHLOROACETANILIDE;4-CHLORACETANILIDE;LABOTEST-BB LT00792311;P-CHLOROACETANILIDE
CAS:539-03-7
MF:C8H8ClNO
MW:169.61
EINECS:208-707-8
Product Categories:Amines;Aromatics;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Anilines, Amides & Amines;Chlorine Compounds
Mol File:539-03-7.mol
4'-CHLOROACETANILIDE Structure
4'-CHLOROACETANILIDE Chemical Properties
Melting point 176-178 °C(lit.)
Boiling point 333 °C
density 1,385 g/cm3
refractive index 1.5670 (estimate)
Fp 333°C
storage temp. 2-8°C
solubility dioxane: 50 mg/mL hot, clear
pka14.25±0.70(Predicted)
form Crystalline Powder
color White or grayish-beige
Water Solubility Insoluble in water.
Merck 14,2111
BRN 509638
CAS DataBase Reference539-03-7(CAS DataBase Reference)
EPA Substance Registry System4-Chloroacetanilide (539-03-7)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS AE1001000
TSCA Yes
HS Code 29242990
Hazardous Substances Data539-03-7(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
4'-CHLOROACETANILIDE Usage And Synthesis
Chemical Propertieswhite or greyish-beige crystalline powder
Uses4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.
DefinitionChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.
Synthesis Reference(s)Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4
General Description4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.
Purification MethodsCrystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]
4'-CHLOROACETANILIDE Preparation Products And Raw materials
Preparation ProductsN-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID-->Ethanone,1-(2-amino-5-chlorophenyl)--->2,6-DICHLORO-1,4-BENZOQUINONE-->2'-Chloroacetanilide-->5-Chloroorthanilic acid-->N-(4-CHLOROPHENYL)-N-ETHYLFORMAMIDE
2-CHLORO-N-(2,4-DICHLOROPHENYL)ACETAMIDE 3,4-DICHLOROACETANILIDE 5-Chloroisatin 5-BROMO-4'-CHLOROSALICYLANILIDE 1-(2,4,6-Trichlorophenyl)-3-amino-pyrazolin-5-one 2,4,5-TRICHLOROACETANILIDE AURORA 3901 N-(4-Chlorophenyl)-2-chloroacetamide N-(4-chlorophenyl)-2-methyl-benzamide N1-(2,4-DICHLOROPHENYL)BENZAMIDE 2'-BENZOYL-2,4'-DICHLOROACETANILIDE 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide N-(4-CHLORO-PHENYL)-OXALAMIC ACID ETHYL ESTER 4'-Chloro-2'-methylacetoacetanilide N1-(4-CHLORO-2-METHYLPHENYL)-2-CHLOROACETAMIDE AURORA 2242 AURORA 3392 N-(4-CHLOROPHENYL)MALEAMIC ACID
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