2,4-Dihydroxypyrimidine-5-carboxylic acid

2,4-Dihydroxypyrimidine-5-carboxylic acid Basic information

Product Name:	2,4-Dihydroxypyrimidine-5-carboxylic acid
Synonyms:	1,2,3,4-TETRAHYDRO-2,4-DIOXO-5-PYRIMIDINECARBOXYLIC ACID;2,4-DIHYDROXYPYRIMIDINE-5-CARBOXYLIC ACID;5-CARBOXY-2,4-DIHYDROXYPYRIMIDINE;5-CARBOXYURACIL extrapure;2,4-Dioxo-11,2,3,4-tetrahydropyrimidine-5-carboxylic acid;2,4-Dioxo-1H-pyrimidine-5-carboxylic acid;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo-;1,2,3,6-Tetrahydro-2,6-dioxo-5-pyrimidinecarboxylic acid
CAS:	23945-44-0
MF:	C5H4N2O4
MW:	156.1
EINECS:	245-947-2
Product Categories:	Heterocycle-Pyrimidine series;Bases & Related Reagents;Nucleotides;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Pyridine;Nucleotides and Nucleosides
Mol File:	23945-44-0.mol

2,4-Dihydroxypyrimidine-5-carboxylic acid Chemical Properties

Melting point	283 °C (dec.)(lit.)
Boiling point	280.29°C (rough estimate)
density	1.6814 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO
pka	5.08±0.20(Predicted)
form	Crystalline Powder
color	White to slightly yellow
Water Solubility	1.8g/L(20 ºC)
CAS DataBase Reference	23945-44-0(CAS DataBase Reference)
EPA Substance Registry System	5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo- (23945-44-0)

Safety Information

MSDS Information

Provider	Language
Uracil-5-carboxylic acid	English
SigmaAldrich	English

2,4-Dihydroxypyrimidine-5-carboxylic acid Usage And Synthesis

Chemical Properties	white to slightly yellow crystalline powder or
Uses	2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been used for the visual sensing of melamine (at parts-per-billion (ppb) level) by a highly sensitive analytical method based on Au nanoparticles.
Definition	ChEBI: Uracil-5-carboxylic acid is a pyrimidinemonocarboxylic acid that is uracil carrying a carboxy group at position 5. It is functionally related to a uracil. It is a conjugate acid of a uracil-5-carboxylate. It is a tautomer of a 2,4-dihydroxypyrimidine-5-carboxylic acid.
General Description	2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. It has been used to synthesize N1-alkylated uracil derivatives.

2,4-Dihydroxypyrimidine-5-carboxylic acid Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium hydroxide-->Sodium-->Urea-->Triethyl orthoformate-->Diethyl malonate-->5-Hydroxymethyluracil-->2,4-DIMETHOXY-5-PYRIMIDINECARBOXYLIC ACID-->ETHYL N-(2-CYANO-3-ETHOXYACRYLOYL)CARBAMATE-->5-Cyanouracil-->Thymine
Preparation Products	isopropanyl 2,4-dichloropyriMidine-5-carboxylate-->5-FORMYLURACIL

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