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| | Mosapride Basic information |
| | Mosapride Chemical Properties |
| Melting point | 151-153°C | | Boiling point | 549.2±50.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 13.52±0.46(Predicted) | | color | White to Off-White | | CAS DataBase Reference | 112885-41-3(CAS DataBase Reference) |
| | Mosapride Usage And Synthesis |
| Description | Mosapride citrate, a new gastroprokinetic benzamide was introduced in
Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with
chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use.
Mosapride is synthesized by final amidation between the corresponding benzoic
acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the
appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist
without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In
dogs, mosapride was as potent as cisapride to stimulate antral and duodenal
motility. In most of species including man, mosapride undergoes extensive
cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but
has potent 5-HT3 antagonist activity. | | Chemical Properties | White to Off-White Crystalline Solid | | Originator | Dainippon (Japan) | | Uses | gastroprokinetic agent | | Uses | A selective 5-HT4 receptor agonist. Gastroprokinetic. | | Definition | ChEBI: Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride. | | Brand name | Gasmotin | | Hazard | A poison by ingestion. | | Safety Profile | A poison by ingestion.
When heated to decomposition it emits
toxic vapors of NOx, F-, and Cl-. |
| | Mosapride Preparation Products And Raw materials |
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