ChemicalBook Product Catalog API Nervous system drugs Drug Metabolism in Human Brain Nefiracetam

Nefiracetam

Nefiracetam Basic information
Product Name:Nefiracetam
Synonyms:n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamide;NEFIRACETAM;2-oxo-1-pyrrolidinylaceticacid,2,6-dimethylanilide;dm9384;dmppa;n-(2,6-dimethylphenyl)-2-oxo-1-pyrrolidineacetamid;DM-9384, (2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide);DMMPA
CAS:77191-36-7
MF:C14H18N2O2
MW:246.3
EINECS:636-080-4
Product Categories:Pharmaceutical intermediate;TRANSLON;Nootropic;Smart drug;BDO
Mol File:77191-36-7.mol
Nefiracetam Structure
Nefiracetam Chemical Properties
Melting point 151-155°C
Boiling point 458.5±33.0 °C(Predicted)
density 1.187±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO: >5mg/mL
pka13.77±0.70(Predicted)
form solid
color white to off-white
Merck 14,6439
InChIInChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)
InChIKeyNGHTXZCKLWZPGK-UHFFFAOYSA-N
SMILESN1(CC(NC2=C(C)C=CC=C2C)=O)CCCC1=O
CAS DataBase Reference77191-36-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
RTECS UX9655650
HS Code 2933.79.1500
ToxicityLD50 in mice (mg/kg): 421 i.v.; 1766 orally (Betzing, 1982)
MSDS Information
Nefiracetam Usage And Synthesis
Usesanalgesic, antiinflammatory
UsesNefiracetam improves post-ischemia evoke-nonconvulsive seizure by altering pro-inflammatory cytokines.
DefinitionChEBI: Nefiracetam is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.
Biological ActivityCognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo .
storageStore at RT
Nefiracetam Preparation Products And Raw materials
Raw materials2,6-Dimethylaniline-->2-Chloro-N-(2,6-dimethylphenyl)acetamide-->Formaldehyde-->2-Pyrrolidinone-->4-Aminobutyric acid
Piracetam Nefiracetam Gabapentin Oxiracetam Citalopram Aniracetam Pramiracetam N-Methyl-2-pyrrolidone Pyrrocaine Pyrrole Polyvinylpyrrolidone 1-(2-aminoethyl)pyrrolidin-2-one MONOETHYLGLYCINEXYLIDIDE N-(2-METHYLPHENYL)-2-(PROPYLAMINO)ACETAMIDE N,N-Dimethylacetamide Lidocaine 1-[2-OXO-2-(4,4,6-TRIMETHYL-1-THIOXO-1,4-DIHYDRO-5H-[1,2]DITHIOLO[3,4-C]QUINOLIN-5-YL)ETHYL]PYRROLIDINE-2,5-DIONE Pyrrolidine
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