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| | TALAMPICILLIN Basic information |
| Product Name: | TALAMPICILLIN | | Synonyms: | 3-Phthalidyl D-2-amino-2-phenylacetamidopenicillanic acid;TALAMPICILLIN;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, [2S-[2a,5a,6b(S*)]]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, (2S,5R,6R)- (9CI);Ampicillin phthalidyl ester;(6R)-6-[[(R)-2-Amino-2-phenylacetyl]amino]penicillanic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester;C11751;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, (2S,5R,6R)- | | CAS: | 47747-56-8 | | MF: | C24H23N3O6S | | MW: | 481.52 | | EINECS: | 256-332-3 | | Product Categories: | | | Mol File: | 47747-56-8.mol |  |
| | TALAMPICILLIN Chemical Properties |
| Boiling point | 770.9±60.0 °C(Predicted) | | density | 1.48±0.1 g/cm3(Predicted) | | pka | 12.15±0.60(Predicted) |
| | TALAMPICILLIN Usage And Synthesis |
| Originator | Talpen,Beecham,US,1975 | | Uses | Antibacterial. | | Definition | ChEBI: Talampicillin is a penicillanic acid ester that is the 1-phthalidyl ester of ampicillin. It is a prodrug of ampicillin. It has a role as a prodrug. It is functionally related to an ampicillin and an o-phthalaldehydic acid. | | Manufacturing Process | A fine suspension of 25.18 grams (0.05 mol) of potassium salt of enamine
protected ampicillin and 10.65 grams (0.05 mol) 3-bromophthalide were
reacted in a 1:2 mixture of acetone/ethyl acetate (1,500 ml) for 24 hours.
After filtration the organic layer was washed twice with 250 ml portions of 1 N
sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and
concentrated in vacuo. Addition of ether crystallized the phthalide enamine
protected α-aminophenylacetamido penicillanate in 85% yield. | | Therapeutic Function | Antibacterial |
| | TALAMPICILLIN Preparation Products And Raw materials |
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