ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic ketones 4-(2-Bromoacetyl)benzonitrile

4-(2-Bromoacetyl)benzonitrile

4-(2-Bromoacetyl)benzonitrile Basic information
Product Name:4-(2-Bromoacetyl)benzonitrile
Synonyms:4-(2-BROMOACETYL)BENZONITRILE;4-(BROMOACETYL)BENZONITRILE;2-BROMO-4'-CYANOACETOPHENONE;BUTTPARK 41\03-55;cyanophenacylbromide;p-Bromoacetylbenzonitrile;4-Cyanophenacyl bromide 97%;4-CYANO 2-BROMO ACETOPHENONE
CAS:20099-89-2
MF:C9H6BrNO
MW:224.05
EINECS:606-435-8
Product Categories:intermediates;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
Mol File:20099-89-2.mol
4-(2-Bromoacetyl)benzonitrile Structure
4-(2-Bromoacetyl)benzonitrile Chemical Properties
Melting point 92-96 °C(lit.)
Boiling point 342.4±22.0 °C(Predicted)
density 1.56±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Methanol
form Crystalline Powder
color Off-white to light yellow
BRN 2087648
InChIKeyLJANCPRIUMHGJE-UHFFFAOYSA-N
CAS DataBase Reference20099-89-2(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 20/21/22-34
Safety Statements 26-27-36/37/39-45
RIDADR UN 2928 6.1/PG 2
WGK Germany 3
Hazard Note Corrosive
HazardClass 6.1
PackingGroup II
HS Code 29269090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
4-(2-Bromoacetyl)benzonitrile Usage And Synthesis
Chemical Propertiesoff-white to light yellow crystalline powder
Uses4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors.
Uses2-Bromo-4′-cyanoacetophenone may be used to synthesize:
  • 3-acylindolizines
  • (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
  • 1-[2-(4-cyanophenyl)-2-oxoethyl]-1,10-phenanthrolinium bromide
General Description2-Bromo-4′-cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile Preparation Products And Raw materials
Preparation ProductsN-methylacridine-->Ravuconazole-->Ravuconazole-->4-(2-Hydroxyacetyl)benzonitrile-->4-oxiran-2-ylbenzonitrile
Isavuconazole Impurity 9 Isavuconazole Impurity 15 Isavuconazole Impurity 3 Isavuconazole Impurity 8 Eltrombopag Impurity 2 Isavuconazole Impurity 21 Isavuconazole Impurity 31 Isavuconazole Impurity 34 Isavuconazole Impurity 13 Isavuconazole Impurity 14 Isavuconazole Impurity 19 Isavuconazole Impurity 24 4-METHYLPHENETHYL BROMIDE 97 ETHYL 2-BROMO-3-(4-CYANOYPHENYL)-3-OXO-PROPANOATE 2-Bromoacetophenone 4-Ethylbenzonitrile 4-(2-BROMO-PENTANOYL)-BENZONITRILE 3-CYANOPHENACYL BROMIDE,3-Cyanophenacyl bromide 95%
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