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Cefmetazole sodium

Cefmetazole sodium Basic information
Product Name:Cefmetazole sodium
Synonyms:Cefmetazone;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-cis)-;Cefmetazole-Na;CS-1170 sodium salt;Metafar;Sodium cefmetazole;(6R,7S)-7-[[2-[(Cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl -1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene -2-carboxylic Acid Sodium Salt
CAS:56796-39-5
MF:C15H18N7NaO5S3
MW:495.52
EINECS:627-393-7
Product Categories:Sulfur & Selenium Compounds;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity
Mol File:56796-39-5.mol
Cefmetazole sodium Structure
Cefmetazole sodium Chemical Properties
Melting point >130°C (dec.)
storage temp. Inert atmosphere,2-8°C
solubility H2O: soluble50mg/mL
form powder
color White to Off-White
Water Solubility Soluble in water
Sensitive Hygroscopic
Merck 14,1926
Stability:Hygroscopic
InChIKeyBITQGIOJQWZUPL-PBCQUBLHSA-M
CAS DataBase Reference56796-39-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 36/37/38-42/43
Safety Statements 26-36
WGK Germany 2
RTECS XI0372200
HS Code 2941.90.3000
ToxicityLD50 i.v. in rats: >5000 mg/kg (Masuda)
MSDS Information
Cefmetazole sodium Usage And Synthesis
Chemical PropertiesWhite Solid
UsesSemi-synthetic antibiotic derived from Cephamycin. Antibacterial
UsesCefmetazole sodium is used clinically in combination with Tanreqing for the treatment of Pulmonary infections like Senile Emphysema and other acute bacterial infections.
DefinitionChEBI: An organic sodium salt that is the sodium salt of cefmetazole.
Brand nameZefazone (Pharmacia & Upjohn）.
Clinical UseCefmetazole (Zefazone) is a semisynthetic, third-generation,parenteral cephalosporin of the cephamycin group. Likeother cephamycins, the presence of the 7α-methoxyl groupconfers resistance to many β-lactamases. Cefmetazoleexhibits significantly higher potency against members ofthe Enterobacteriaceae family but lower activity againstBacteroides spp. than cefoxitin. It is highly active againstN. gonorrhoeae, including -lactamase–producing strains. Incommon with other cephamycins, cefmetazole is ineffectiveagainst indole-positive Proteus, Enterobacter, Providencia,Serratia, and Pseudomonas spp. Cefmetazole has the MTTmoiety associated with increased bleeding in certain highriskpatients. It has a plasma half-life of 1.1 hours.
Cefmetazole sodium Preparation Products And Raw materials
Acetyl-resveratrol Sodium alginate Sodium benzoate Sodium acetate Acetaminophen ACETAMINOPHENOL BP/USP Acetylacetone sodium Methoxy Sodium chloride Trisodium phosphate Acetyl chloride Diclofenac sodium Acetyl coenzyme A sodium salt Sodium citrate Sodium bicarbonate Sodium hydroxide CEFMETAZOLE SODIUM SALT
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