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| | FMOC-S-trityl-L-cysteine Basic information |
| | FMOC-S-trityl-L-cysteine Chemical Properties |
| Melting point | 170-173 °C(lit.) | | Boiling point | 763.4±60.0 °C(Predicted) | | alpha | 16 º (c=1, THF) | | density | 1.270±0.06 g/cm3(Predicted) | | refractive index | 18 ° (C=1, THF) | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 3.70±0.10(Predicted) | | form | Powder | | color | White to almost white | | optical activity | [α]20/D +16.0±2°, c = 1% in THF | | Water Solubility | Insoluble in water. Soluble in most organic solvents. | | BRN | 4221286 | | InChIKey | KLBPUVPNPAJWHZ-UMSFTDKQSA-N | | CAS DataBase Reference | 103213-32-7(CAS DataBase Reference) |
| | FMOC-S-trityl-L-cysteine Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative used in peptide synthesis. Some of the examples are:
- Synthesis of mono- and bi-functionalized platinum(IV) complexes to target angiogenic tumor vasculature.
- Synthesis of proteins through native chemical ligation of peptide hydrazides as thioester surrogates via solid-phase synthesis.
- Synthesis of glycoconjugates by conjugating reducing sugars to cysteine residues of peptides.
| | Uses | It is potentially useful for proteomics studies, and solid phase peptide synthesis techniques. Cysteine is versatile amino acid involved with many biological processes, including the formation of disulfide bonds - a critical component of protein structure. This compound could be useful as an unusual amino acid analog to aid in the deconvolution of protein structure and function. | | General Description | The standard derivative for Fmoc SPPS of peptides containing Cys [1]. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation [2,3] to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP?, is to be employed, it is strongly recommended that collidine is used as the base [4], as this has been shown to significantly reduce loss of optical integrity during coupling.
The product number for this product was previously 04-12-1018.
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| | FMOC-S-trityl-L-cysteine Preparation Products And Raw materials |
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