|
| | Methylophiopogonanone A Basic information |
| Product Name: | Methylophiopogonanone A | | Synonyms: | Methylophiopogonanone A;(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one;Methylophiopogonanone A(R-Methylophiopogonanone A);8-Methylophiopogonanone A;(3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one;R-Methylophiopogonanone A;Methylophiopogonanone A (MO-A);4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)- | | CAS: | 74805-92-8 | | MF: | C19H18O6 | | MW: | 342.34 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 74805-92-8.mol |  |
| | Methylophiopogonanone A Chemical Properties |
| Boiling point | 580.1±50.0 °C(Predicted) | | density | 1.410 | | solubility | Soluble in chloroform and methanol; | | form | powder | | pka | 8.24±0.40(Predicted) | | color | Light yellow | | Water Solubility | insoluble in water |
| | Methylophiopogonanone A Usage And Synthesis |
| Description | Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities. It increases the uptake of rosuvastatin (Item Nos. 12029 | 18813) and atorvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 μM, respectively). Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals in cell-free assays. In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia. It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery. | | Definition | ChEBI: Methylophiopogonanone A is a homoflavonoid. | | target | MMP(e.g.TIMP) |
| | Methylophiopogonanone A Preparation Products And Raw materials |
|
