ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Lysine derivatives N-alpha-FMOC-Nepsilon-BOC-L-Lysine

N-alpha-FMOC-Nepsilon-BOC-L-Lysine

N-alpha-FMOC-Nepsilon-BOC-L-Lysine Basic information
Product Name:N-alpha-FMOC-Nepsilon-BOC-L-Lysine
Synonyms:Nα-FMoc-Nε-Boc-L-lysine;N^e-Boc-N^a-FMoc-L-lysine, 98%;ALPHA-FMOC-EPSILON-BOC-LYSINE;FMOC-D-LYSINE(BOC)-OH;FMOC-L-LYS(TBOC)-OH;FMOC-L-LYSINE(BOC);FMOC-L-LYSINE (TBOC);FMOC-N-EPSILON-BOC-D-LYSINE
CAS:71989-26-9
MF:C26H32N2O6
MW:468.54
EINECS:276-256-4
Product Categories:Amino Acid Derivatives;Amino Acids;Lysine [Lys, K];Fmoc-Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Fmoc-Amino Acids;Fmoc-Amino acid series
Mol File:71989-26-9.mol
N-alpha-FMOC-Nepsilon-BOC-L-Lysine Structure
N-alpha-FMOC-Nepsilon-BOC-L-Lysine Chemical Properties
Melting point 130-135 °C (dec.)
alpha -12 º (c=2,DMF 24 ºC)
Boiling point 570.69°C (rough estimate)
density 1.2301 (rough estimate)
refractive index -12 ° (C=1, DMF)
storage temp. Store below +30°C.
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka3.88±0.21(Predicted)
form Powder
color White
optical activity[α]20/D 12±1°, c = 1% in DMF
Water Solubility Slightly soluble in water.
BRN 4217767
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyUMRUUWFGLGNQLI-QFIPXVFZSA-N
CAS DataBase Reference71989-26-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 24/25-36/37/39-27-26
WGK Germany 3
HS Code 29224999
MSDS Information
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N-alpha-FMOC-Nepsilon-BOC-L-Lysine English
SigmaAldrich English
ACROS English
N-alpha-FMOC-Nepsilon-BOC-L-Lysine Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powde
UsesFmoc-Lys(Boc)-OH can be used for:
  • The solid-phase synthesis of pentasubstituted dihydroimidazolylbutyl dihydroimidazol-3-ium salts by coupling with p-methylbenzhydrylamine (MBHA) resin.
  • Fmoc-based peptide synthesis of bis-naphthalene diimide, a threading intercalator.
  • Synthesis of ε-Boc-ε-(3,5-bis-trifluoromethyl-benzyl)-α-Fmoc-L-Lysine to be used as 19F NMR based screening tool.

UsesIt is used to prepare dimeric RGD peptide-paclitaxel conjugate as model for integrin-targeted drug delivery. It is also used to synthesize DOTA-conjugated multivalent cyclic-RGD peptide dendrimers for tumor targeting and imaging use.
N-alpha-FMOC-Nepsilon-BOC-L-Lysine Preparation Products And Raw materials
Preparation ProductsFMOC-LYS(TEOC)-OH-->L-Lysine, N6-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]--->FMOC-LYS(BIOTIN)-OH-->Fmoc-L-Lys(Dde)-OH-->Copper Peptide-->(S)-2-(allyloxycarbonylaMino)-6-(tert-butoxycarbonylaMino)hexanoic acid-->FMOC-LYS(BOC)-OPFP
FMOC-(4-CIS/TRANS)-1, 1-ACCH(4-CH2-NH-BOC) NOMEGA-tert-Butoxycarbonyl-NALPHA-9-fluorenylmethoxycarbonyl-L-lysine NALPH FMOC-(2S, 5S)-LYSINE(5-OH, N-BOC) (S,S)-N-ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-(S)-3-(N'-T-BUTYLOXYCARBONYL-AZETIDIN-2-YL)-ALANINE (2S5R)-N-ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-PYRROLIDINE-5-(N'-T-BUTYLOXYCARBONYL-AMINOMETHYL)-2-CARBOXYLIC ACID FMOC-(FMOCHMB)LYS(BOC)-OH Fmoc-Aib-OH N-ALPHA-FMOC-BETA-(1-BOC-PIPERIDIN-4-YL)-D,L-ALANINE FMOC-LYS(BOC)(ISOPROPYL)-OH N'-(tert-Butoxycarbonyl)-N-(9-fluorenylmethyloxycarbonyl)-D-lysine pentafluorophenyl ester FMOC-(2S)-TRANS-CHG(4-NH-BOC) FMOC-(2S, 3R)-GLY-3-PIP(BOC) FMOC-L-LYS(BOC, CHX)-OH FMOC-LYS(ADPOC)-OH FMOC-L-ALA[3-(3S)PYRROLIDINYL(BOC)] FMOC-L-LYS(BOC, BZL)-OH FMOC-LYS(BOC)-OPFP DI-TERT-BUTYL ETHER
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