ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Thiophene compounds 2-(4-Fluorophenyl)-thiophene

2-(4-Fluorophenyl)-thiophene

2-(4-Fluorophenyl)-thiophene Basic information
Product Name:2-(4-Fluorophenyl)-thiophene
Synonyms:IFLAB-BB F2108-0130;2-(4-FLUOROPHENYL)THIOPHENE;AKOS BAR-1344;Thiophene, 2-(4-fluorophenyl)-;Canagliflozin intermediate;Canagliflozin Intermediate I;Canagliflozin INT2;2-(4-fluorophenyl)thiophen
CAS:58861-48-6
MF:C10H7FS
MW:178.23
EINECS:611-756-1
Product Categories:58861-48-6
Mol File:58861-48-6.mol
2-(4-Fluorophenyl)-thiophene Structure
2-(4-Fluorophenyl)-thiophene Chemical Properties
Melting point 51.0 to 55.0 °C
Boiling point 252.3±15.0 °C(Predicted)
density 1.200±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility soluble in Methanol
form powder to crystal
color Light orange to Yellow to Green
InChIInChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H
InChIKeyPURJRGMZIKXDMW-UHFFFAOYSA-N
SMILESC1(C2=CC=C(F)C=C2)SC=CC=1
CAS DataBase Reference58861-48-6
Safety Information
HS Code 2934999090
MSDS Information
2-(4-Fluorophenyl)-thiophene Usage And Synthesis
Chemical Propertieswhite solid
Uses2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.
Synthesis4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.
2-(4-Fluorophenyl)-thiophene Preparation Products And Raw materials
Preparation Products5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI&-->(5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone
5-(4-FLUOROPHENYL)-N-PHENYL-2-THIOPHENECARBOXAMIDE 3-TERT-BUTOXYCARBONYLAMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLIC ACID METHYL 5-(4-FLUOROPHENYL)-3-[(2,3,3-TRICHLOROACRYLOYL)AMINO]THIOPHENE-2-CARBOXYLATE 1-[3-AMINO-5-(4-FLUOROPHENYL)-2-THIENYL!ETHAN-1-ONE, 97 3-TERT-BUTOXYCARBONYLAMINO-5-(4-FLUOROPHENYL)-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID BUTTPARK 62\18-34 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXAMIDE 5-(4-FLUOROPHENYL)-N-METHYL-N-PHENYL-2-THIOPHENECARBOXAMIDE 3-[(2-CHLOROACETYL)AMINO]-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXAMIDE 3-AMINO-2-CYANO-5-(4-FLUOROPHENYL)THIOPHENE,3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBONITRILE METHYL 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE 4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE 6-(4-FLUOROPHENYL)-3,4-DIHYDROTHIENO[3,2-D]-PYRIMIDIN-4-ONE 3-AMINO-5-(4-FLUOROPHENYL)-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER METHYL 5-(4-FLUOROPHENYL)-2-THIOPHENECARBOXYLATE DUP-697 5-(4-FLUOROPHENYL)-3-[(2,3,3-TRICHLOROACRYLOYL)AMINO]THIOPHENE-2-CARBOXAMIDE 5-(4-FLUOROPHENYL)-N-METHYL-2-THIOPHENECARBOXAMIDE
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