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| | Isosorbide Basic information |
| | Isosorbide Chemical Properties |
| Melting point | 60-63 °C (lit.) | | alpha | 42 º (c=3, H2O) | | Boiling point | 175°C/2mmHg(lit.) | | density | 1.0945 (rough estimate) | | vapor pressure | 0.007Pa at 20℃ | | refractive index | 45 ° (C=5, H2O) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | pka | 13.17±0.40(Predicted) | | form | Crystals, Crystalline Solid or Mass | | color | Off-white to light yellow or beige | | optical activity | [α]20/D +45.2°, c = 3 in H2O | | Water Solubility | Soluble in alcohols, water and ketones. | | Sensitive | Hygroscopic | | Merck | 14,5224 | | BRN | 80510 | | InChIKey | KLDXJTOLSGUMSJ-JGWLITMVSA-N | | LogP | -1.39 at 20℃ | | CAS DataBase Reference | 652-67-5(CAS DataBase Reference) | | EPA Substance Registry System | D-Glucitol, 1,4:3,6-dianhydro- (652-67-5) |
| | Isosorbide Usage And Synthesis |
| Chemical Properties | off-white to light yellow or beige crystals, | | Uses | Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.
| | Uses | pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics. | | Uses | D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters. | | Definition | A polyol with a hydroxyl group attached to each of
two cis-oriented saturated furan rings. Intermediate
for pharmaceuticals. Combustible. | | Brand name | Ismotic (Alcon). | | Biological Functions | emergency treatment of acute angle-closure glaucoma.
It should not be confused with isosorbide dinitrate, an
antianginal drug. | | Flammability and Explosibility | Nonflammable | | Clinical Use | Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its
ophthalmologic properties are its primary value. |
| | Isosorbide Preparation Products And Raw materials |
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