ChemicalBook Product Catalog Chemical Reagents Organic reagents Esters Ethyl compound Ethyl 4,4,4-trifluoroacetoacetate

Ethyl 4,4,4-trifluoroacetoacetate

Ethyl 4,4,4-trifluoroacetoacetate Basic information
Product Name:Ethyl 4,4,4-trifluoroacetoacetate
Synonyms:Ethyl4,4,-Trifluoroacetoacetate;Ethyltrifluoroacetoacetate,98+%;ETHYL 4,4,4-TRIFLUOROACETYLACETATE;ETFAA;1-Ethoxy-4,4,4-trifluorobutane-1,3-dione;Ethyl 3-oxo-4,4,4-trifluorobutanoate;Ethyl 4,4,4-trifluoro-3-oxobutyrate;(Trifluoroacetyl)acetic acid ethyl ester
CAS:372-31-6
MF:C6H7F3O3
MW:184.11
EINECS:206-750-7
Product Categories:Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Aliphatics;Esters;Organic Fluorides;Synthetic Organic Chemistry;Pharmaceutical Intermediates;Fluorochemicals;top;bc0001;372-31-6
Mol File:372-31-6.mol
Ethyl 4,4,4-trifluoroacetoacetate Structure
Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties
Melting point -39 °C
Boiling point 129-130 °C(lit.)
density 1.259 g/mL at 25 °C(lit.)
vapor pressure 8hPa at 20℃
refractive index n20/D 1.375(lit.)
Fp 84 °F
storage temp. Sealed in dry,Room Temperature
solubility 10g/l
pka7.76±0.10(Predicted)
form Liquid
color Clear colorless to slightly yellow
Specific Gravity1.259 (20/4℃)
PH6.2 (10g/l, H2O, 20℃)
Water Solubility 10 g/L (20 ºC)
BRN 608353
InChIKeyOCJKUQIPRNZDTK-UHFFFAOYSA-N
CAS DataBase Reference372-31-6(CAS DataBase Reference)
NIST Chemistry ReferenceButanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester(372-31-6)
EPA Substance Registry SystemEthyl 4,4,4-trifluoroacetoacetate (372-31-6)
Safety Information
Hazard Codes Xn,F,C,Xi
Risk Statements 10-22-52/53
Safety Statements 61-16
RIDADR UN 3272 3/PG 3
WGK Germany 2
Hazard Note Flammable/Corrosive
TSCA T
HazardClass 3
PackingGroup III
HS Code 29183000
MSDS Information
ProviderLanguage
Ethyl 3-oxo-4,4,4-trifluoroacetoacetate English
ACROS English
SigmaAldrich English
ALFA English
Ethyl 4,4,4-trifluoroacetoacetate Usage And Synthesis
Chemical PropertiesClear liquid
UsesIntermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet
UsesWidely used in the synthetic process of medicine, pesticides and organic intermediate.
UsesEthyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.
Flammability and ExplosibilityFlammable
Ethyl 4,4,4-trifluoroacetoacetate Preparation Products And Raw materials
Raw materialsTrifluoroacetic acid
Preparation Products4-BROMO-6-(TRIFLUOROMETHYL)PYRIMIDINE-->5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE-->(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE-->4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97%-->5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE-->4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID-->6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97%-->ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate-->4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97%-->(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL-->4-(Trifluoromethyl)quinolin-2-amine-->5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE-->(4-(Trifluoromethyl)quinolin-2-yl)methanol ,97%-->(6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97%-->1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE-->(1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL-->(5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE-->(5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL-->7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN-->4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE-->4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE-->1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID-->ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->4-Methylpyrimidine-->ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE-->4-bromo-2-(trifluoromethyl)quinoline-->Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97%-->4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE-->2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-->ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL-->2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE-->2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline-->4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE
Ethyl trifluoroacetate tert-Butyl acetoacetate Ethyl bromodifluoroacetate Ethanol Acetoxyacetic acid Ethyl 4-chloroacetoacetate Ethyl formate Ethylbenzene Ethylparaben Methyl acetoacetate CHLOROETHANE Ethyl cellulose Diethyl ether Ethyl acetate Ethyl acrylate Ethyl 2-methylacetoacetate Ethyl 2-chloroacetoacetate Ethyl 4-bromoacetoacetate Ethyl Trifluoroacetoacetate
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