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| | SCE 2174 Basic information |
| Product Name: | SCE 2174 | | Synonyms: | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, dihydrochloride, (6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, dihydrochloride, [6R-(6α,7β)]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, hydrochloride (1:2), (6R,7R)-;SCE 2174;1-cyclohexyloxycarbonyloxyethyl (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate dihydrochloride;(6R-(6-alpha,7-beta))-7-(((2-Amino-4-thiazolyl)acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester dihydrochloride;Cefotiam
(mixture of Diastereomers);Cefotiam Hexetil 2HCl | | CAS: | 95789-30-3 | | MF: | C27H38ClN9O7S3 | | MW: | 732.29 | | EINECS: | 680-797-5 | | Product Categories: | Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds | | Mol File: | 95789-30-3.mol |  |
| | SCE 2174 Chemical Properties |
| Melting point | 120-130°C | | storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Pale Yellow | | CAS DataBase Reference | 95789-30-3 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 1290, 1150, 1470, 1620 i.p.; >2000 s.c.; >5000 orally (Chiba) |
| | SCE 2174 Usage And Synthesis |
| Description | Cefotiam hexetil hydrochloride is an orally active, broad-spectrum cephalosporin
useful in the treatment of bacterial infections. It is a prodrug hydrolyzed in the GI tract
and absorbed as cefotiam. Cefotiam hexetil hydrochloride is reported to be especially
potent against Streptococci strains. | | Chemical Properties | Off-White to Pale Yellow Solid | | Originator | Takeda (Japan) | | Uses | A semi-synthetic cephalosporin antibiotic. Antibacterial. | | Definition | ChEBI: The dihydrochloride salt of cefotiam 1-(cyclohexyloxycarbonyloxy)ethyl ester. It is used as a prodrug for cefotiam. | | Brand name | Pansporin T |
| | SCE 2174 Preparation Products And Raw materials |
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