BENZYL 3-PYRROLINE-1-CARBOXYLATE

BENZYL 3-PYRROLINE-1-CARBOXYLATE Basic information

Product Name:	BENZYL 3-PYRROLINE-1-CARBOXYLATE
Synonyms:	benzyl 2,5-dihydropyrrole-1-carboxylate;2,5-Dihydro-1H-pyrrole, N-CBZ protected;2,5-dihydropyrrole-1-carboxylic acid (phenylmethyl) ester;N-Cbz 2,5-dihydro-1H-pyrrole;benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate;N-(Benzyloxycarbonyl)3-pyrroline;2,5-Dihydropyrrole-1-Cbz;N-Cbz-2,5-dihydropyrrole
CAS:	31970-04-4
MF:	C12H13NO2
MW:	203.24
EINECS:
Product Categories:	Building Blocks;Heterocyclic Building Blocks;Pyrrolines
Mol File:	31970-04-4.mol

BENZYL 3-PYRROLINE-1-CARBOXYLATE Chemical Properties

Boiling point	133-137 °C0.6 mm Hg(lit.)
density	1.132 g/mL at 25 °C(lit.)
refractive index	n20/D 1.544(lit.)
Fp	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-1.51±0.20(Predicted)
form	Liquid
color	Colorless to pale yellow
CAS DataBase Reference	31970-04-4

Safety Information

MSDS Information

BENZYL 3-PYRROLINE-1-CARBOXYLATE Usage And Synthesis

Chemical Properties	Colorless liquid
Uses	Benzyl 3-Pyrroline-1-carboxylate is an heterocyclic building block used in the synthesis of pharmaceutical products including inhibitors. It is used in synthesis of novel series of pyrrolotriazine, acting as a pan-Aurora kinase inhibitors.

BENZYL 3-PYRROLINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials	N-Cbz-3(S)-fluoropyrrolidine-->Carbamic acid, N,N-di-2-propen-1-yl-, phenylmethyl ester-->benzyl 2,5-dioxopyrrolidine-1-carboxylate-->1-Benzyl-2,5-dihydro-1H-pyrrole-->(R)-1-CBZ-3-PYRROLIDINOL-->2,5-Dihydro-1H-pyrrole hydrochloride-->N-(Benzyloxycarbonyloxy)succinimide-->Phenyl chloroformate-->3-Pyrroline-->Benzyl chloroformate
Preparation Products	1-Pyrrolidinecarboxylic acid, 3-fluoro-, phenylmethyl ester

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