ChemicalBook Product Catalog Chemical Reagents Organic reagents Sulfonates / Sulfinates salts THENIUM CLOSYLATE

THENIUM CLOSYLATE

THENIUM CLOSYLATE Basic information
Product Name:THENIUM CLOSYLATE
Synonyms:THENIUM CLOSYLATE;DIMETHYL(2-PHENOXYETHYL)-2-THENYLAMMONIUM-P-CHLOROBENZENESULFONATE;thenium closilate;Thenium;Bancaris;611C65;NSC-106569
CAS:4304-40-9
MF:C21H24ClNO4S2
MW:454
EINECS:224-318-6
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:4304-40-9.mol
THENIUM CLOSYLATE Structure
THENIUM CLOSYLATE Chemical Properties
Melting point 159-160°C
storage temp. -20°C Freezer
solubility Acetonitrile (Slightly), Methanol, Water (Slightly)
form Solid
color White to Off-White
CAS DataBase Reference4304-40-9
Safety Information
MSDS Information
THENIUM CLOSYLATE Usage And Synthesis
Chemical PropertiesWhite Solid
OriginatorThenium closylate,ZYF Pharm Chemical
UsesActive against parasitic nematodes, especially those of the stomach and intestines.
Manufacturing Process2-Chlormethylthiophene (6.6 g) was added to a solution of 1-dimethylamino- 2-phenoxyethane (8.2 g) in acetone (45 ml). On standing for 30 min an oil separeted. The resulting suspension was heated to reflux for a further 30 min and cooled. On standing, the separated oil partially crystallized. The supernatant liquors were decanted and the residue was recrystallized by dissolution in warm isopropanol and careful precipitation with ethyl acetate or ether to give colourless needles N,N-dimethyl-N-2-phenoxyethyl-N-2'- thenylammonium chloride monohydrate, M.P. 85-86°C.
A solution of free base of the last compound and p-chlorobenzenesulfonic acid (molar ratio 1:1) were reacted together in boiling acetone. After 30 min the solution was cooled and ethyl acetate added to precipitate a colourless solid of N,N-dimethyl-N-(2-phenoxyethyl)-N-(2-thenyl)ammonium 4- chlorbenzolsulfonate.
Therapeutic FunctionAnthelmintic
THENIUM CLOSYLATE Preparation Products And Raw materials
Raw materials4-Chlorobenzenesulfonic acid
THENIUM CLOSYLATE Cholinebisulfite (2-METHOXY-ETHYL)-THIOPHEN-2-YLMETHYL-AMINE
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