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| | 5-fluoro-1H-pyrimidine-2,4-dione Basic information |
| | 5-fluoro-1H-pyrimidine-2,4-dione Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: slightly soluble; Methanol: slightly soluble | | form | A solid |
| | 5-fluoro-1H-pyrimidine-2,4-dione Usage And Synthesis |
| Description | 5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. | | Uses | Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis. |
| | 5-fluoro-1H-pyrimidine-2,4-dione Preparation Products And Raw materials |
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