2-Amino-3-hydroxypyridine

2-Amino-3-hydroxypyridine Basic information

Product Name:	2-Amino-3-hydroxypyridine
Synonyms:	2-Amino-3-hydroxypyridine Vetec(TM) reagent grade, 98%;2-AMINO-3-HYDROXYPYRIDINE;2-AMINO-3-PYRIDINOL;2-AMINO-3-PYRIDOL;2-AMINO-PYRIDIN-3-OL;2-amino-3-pyridi;3-HYDROXY-2-AMINOPYRIDINE;3-PYRIDINOL, 2-AMINO-
CAS:	16867-03-1
MF:	C5H6N2O
MW:	110.11
EINECS:	240-886-8
Product Categories:	Building Blocks;C5;Amines;Aromatics;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Pyridine;Pyridines derivates;Chemical Amines;Pyridines
Mol File:	16867-03-1.mol

2-Amino-3-hydroxypyridine Chemical Properties

Melting point	168-172 °C (lit.)
Boiling point	206.4°C (rough estimate)
density	1.2111 (rough estimate)
vapor pressure	0.007-0.28Pa at 20-50℃
refractive index	1.4800 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	5.15±0.10(Predicted)
form	Crystalline Powder
color	Grayish-beige to brownish
BRN	109868
InChIKey	BMTSZVZQNMNPCT-UHFFFAOYSA-N
LogP	-0.25 at 23℃ and pH7.02-7.04
Surface tension	72.6mN/m at 1.053g/L and 20℃
CAS DataBase Reference	16867-03-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Amino-3-hydroxypyridine(16867-03-1)

Safety Information

Hazard Codes	Xi,T,Xn
Risk Statements	36/37/38-25-40
Safety Statements	26-45-37/39-28A-36-22
RIDADR	UN2811
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29333999

MSDS Information

Provider	Language
2-Amino-3-pyridinol	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Amino-3-hydroxypyridine Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.
Synthesis Reference(s)	Journal of Heterocyclic Chemistry, 14, p. 203, 1977 DOI: 10.1002/jhet.5570140206
General Description	2-Amino-3-hydroxypyridine forms complexes with number of transition metals. It inhibits the corrosion of aluminium and copper in acidic solutions. It undergoes condensation with 2-hydroxy-1-naphthaldehyde and 2-hydroxybenzaldehyde to form Schiffs bases. It is useful in the preparation of clinical anti-inflammatory analgesics.

2-Amino-3-hydroxypyridine Preparation Products And Raw materials

Raw materials	3-Hydroxypicolinic acid-->2-Amino-3-benzyloxypyridine-->3-HYDROXYPICOLINAMIDE-->2-FURAMIDE-->2-Amino-3-ethoxypyridine-->2-IODO-3-HYDROXYPYRIDINE-->3-Hydroxy-2-nitropyridine-->Hexamethylphosphoramide-->3-Nitro-2-pyridinol-->3-Hydroxypyridine
Preparation Products	2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one-->3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one-->Paliperidone Impurity 4-->tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate-->2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one-->N,N-DiMethyl-4-(oxazolo[4,5-b]pyridin-2-yl)aniline-->3-[(3,4-DICHLOROBENZYL)OXY]PYRIDIN-2-AMINE

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one 2-Amino-3-hydroxypyridine 3-ETHOXY-2-NITROPYRIDINE 2-(Acetylamino)-3-pyridyl acetate 7-CHLORO-2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)ONE 2-Amino-3-benzyloxypyridine 2-Nitro-3-hydroxypyridine 2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PYRIDIN-3-OL 3-HYDROXY-6-METHYL-2-NITROPYRIDINE 3-[(3,4-DICHLOROBENZYL)OXY]PYRIDIN-2-AMINE 6-METHYL-2-NITRO-3-PYRIDYL 5-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-4-SULFONATE 2-Aminopyridine Tris(hydroxymethyl)aminomethane AMINO ACIDS 3-[(3-methylphenyl)methoxy]pyridin-2-amine 3-BROMO-2,6-BISNITRO-5-METHOXYPYRIDINE 6-METHYL-2-NITRO-3-PYRIDYL 2-CHLORONICOTINATE

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