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| | SCIADOPITYSIN Basic information |
| Product Name: | SCIADOPITYSIN | | Synonyms: | AMENTOFLAVONE-7,4',4'''-TRIMETHYL ETHER;AMENTOFLAVONE-7,4',4''-TRIMETHYL ETHER;AMENTOFLAVONE-7,4',4'-TRIMETHYL ETHER;SCIADOPITYSIN;5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4-benzopyrone;SCIADOPITYSIN(SH);AMENTOFLAVONE-7,4'',4''-TRIMETHYL ETHER WITH HPLC;2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one | | CAS: | 521-34-6 | | MF: | C33H24O10 | | MW: | 580.54 | | EINECS: | 208-311-5 | | Product Categories: | Tri-substituted Flavones | | Mol File: | 521-34-6.mol |  |
| | SCIADOPITYSIN Chemical Properties |
| Melting point | 296-298°C | | Boiling point | 839.6±65.0 °C(Predicted) | | density | 1.445±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in ethanol and methan | | pka | 6.16±0.40(Predicted) | | form | powder | | color | Light yellow | | LogP | 5.500 (est) | | CAS DataBase Reference | 521-34-6 |
| Safety Statements | 24/25 | | HS Code | 29329990 |
| | SCIADOPITYSIN Usage And Synthesis |
| Description | Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss. | | Definition | ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone. | | target | ROS | MMP(e.g.TIMP) | NO | TNF-α | ATPase | cAMP | Beta Amyloid |
| | SCIADOPITYSIN Preparation Products And Raw materials |
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