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| | Alantolactone Basic information |
| Product Name: | Alantolactone | | Synonyms: | HELENINE;8b-hydroxy-4ah-eudesm-5-en-12-oic acid;ALLANTOLACTONE;ALANTOLACETONE;ALANTOLACTONE;[3ar-(3aa,5b,8ab,9aa)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho-[2,3-b]furan-2(3h)-one;[3aR-(3aalpha,5beta,8abeta,9aalpha)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one;Alantolactone (Helenin) | | CAS: | 546-43-0 | | MF: | C15H20O2 | | MW: | 232.32 | | EINECS: | 208-899-3 | | Product Categories: | Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Alkaloids;chiral | | Mol File: | 546-43-0.mol |  |
| | Alantolactone Chemical Properties |
| Melting point | 78-79 C | | Boiling point | 275 C | | alpha | D +175° (chloroform) | | density | 1.0610 (rough estimate) | | refractive index | 1.4360 (estimate) | | storage temp. | -20°C | | solubility | DMSO: soluble15mg/mL (clear solution) | | form | powder | | color | white to beige | | LogP | 3.380 | | CAS DataBase Reference | 546-43-0(CAS DataBase Reference) |
| | Alantolactone Usage And Synthesis |
| Description | The allergen eudesmanolide sesquiterpene lactone was
isolated from elecampane (Inula helenium L.). With
dehydrocostuslactone and costunolide, it is a component
of the (sesquiterpene) lactone-mix, used to detect
sensitization to Compositae.
| | Chemical Properties | Crystalline powder | | Uses | anthelmintic, antibacterial, antineoplastic | | Uses | Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer. | | Uses | Alantolactone has been used:
- in cell viability assay
- to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
- in assessment of degranulation
| | Definition | ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3. | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | Biochem/physiol Actions | Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells. | | Contact allergens | The allergen eudesmanolide sesquiterpene lactone was
isolated from elecampane (Inula helenium L.). With
dehydrocostuslactone and costunolide, it is a component
of the (sesquiterpene) lactone mix used to detect
sensitization to Compositae-Asteraceae. | | storage | Store at -20°C |
| | Alantolactone Preparation Products And Raw materials |
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