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| | 5-Nitro-1,10-phenanthroline Basic information |
| Product Name: | 5-Nitro-1,10-phenanthroline | | Synonyms: | 5-NITRO-1,10-PHENANTHROLINE;5-nitro-10-phenanthroline;NITROFERROIN;TIMTEC-BB SBB008850;5-NITRO-1 10-PHENANTHROLINE HYDRATE &;5-Nitro-1,10-phenanthroline,98%;1,10-Phenanthroline, 5-nitro-;5-Nitro-1,10-phenathroline | | CAS: | 4199-88-6 | | MF: | C12H7N3O2 | | MW: | 225.2 | | EINECS: | 224-097-6 | | Product Categories: | | | Mol File: | 4199-88-6.mol |  |
| | 5-Nitro-1,10-phenanthroline Chemical Properties |
| Melting point | 202-204 °C(lit.) | | Boiling point | 366.71°C (rough estimate) | | density | 1.2844 (rough estimate) | | refractive index | 1.5700 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Alcohol,Benzene | | form | crystalline | | pka | pK1:3.232(+1) (25°C) | | color | yellow to orange | | Water Solubility | insoluble | | BRN | 196245 | | CAS DataBase Reference | 4199-88-6(CAS DataBase Reference) | | EPA Substance Registry System | 1,10-Phenanthroline, 5-nitro- (4199-88-6) |
| | 5-Nitro-1,10-phenanthroline Usage And Synthesis |
| Chemical Properties | Light yellow to yellow-brown crystalline powder | | Uses | 5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline. | | Biochem/physiol Actions | Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity. | | Purification Methods | Crystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.] |
| | 5-Nitro-1,10-phenanthroline Preparation Products And Raw materials |
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