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| | PluriSln 1 Basic information |
| Product Name: | PluriSln 1 | | Synonyms: | 4-Pyridinecarboxylicacid, 2-phenylhydrazide;plurisln 1;1,4-Pyridinecarboxylicacid;NSC 14613;NSC-14613;NSC14613;PluriSIn #1 - NSC 14613 | Pluripotent cell-specific inhibitor #1;NSC14613,PluriSln1, >98%;NSC 14613;PluriSIn#1 | | CAS: | 91396-88-2 | | MF: | C12H11N3O | | MW: | 213.24 | | EINECS: | 804-702-5 | | Product Categories: | Inhibitors | | Mol File: | 91396-88-2.mol |  |
| | PluriSln 1 Chemical Properties |
| Melting point | 177-178℃ | | Boiling point | 335.7±15.0 °C(Predicted) | | density | 1.251±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: soluble15mg/mL, clear | | pka | 10.69±0.23(Predicted) | | form | powder | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 2933.39.9200 |
| | PluriSln 1 Usage And Synthesis |
| Description | PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1?The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln-1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2?and chondrogenic cells3. | | Uses | NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs. | | storage | +4°C | | References | 1) Ben-David?et al. (2013),?Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen; Cell Stem Cell.?12?167
2) Zhang?et al. (2014),?Inhibition of stearoyl-coA desaturase eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium; Cell Cycle?13?762
3) Cheng?et al. (2014),?Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors; Stem Cells Transl. Med.?3?1287 |
| | PluriSln 1 Preparation Products And Raw materials |
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