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| | PROXYPHYLLINE Basic information |
| Product Name: | PROXYPHYLLINE | | Synonyms: | 7-(BETA-HYDROXYPROPYL)THEOPHYLLINE;[1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE];7-(B-hydroxypropyl)theophylline;Proxylphylline;Proxyphylline BP;1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl- (9CI);2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine;7-(b-Hydroxypropyl)-1,3-dimethylxanthine | | CAS: | 603-00-9 | | MF: | C10H14N4O3 | | MW: | 238.24 | | EINECS: | 210-028-7 | | Product Categories: | Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals | | Mol File: | 603-00-9.mol |  |
| | PROXYPHYLLINE Chemical Properties |
| Melting point | 134-136°C | | Boiling point | 487.2±51.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Solution S is clear (2.2.1) and colourless (2.2.2, Method II). | | form | neat | | pka | 14.55±0.20(Predicted) | | color | White to Off-White | | Water Solubility | 285.7g/L(temperature not stated) | | Merck | 14,7905 | | CAS DataBase Reference | 603-00-9(CAS DataBase Reference) | | NIST Chemistry Reference | Proxyphylline(603-00-9) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | XH5907500 | | HS Code | 2939.59.0000 |
| | PROXYPHYLLINE Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | A metabolite of Theophylline in human plasma. | | Definition | ChEBI: Proxyphylline is an oxopurine. | | Biological Activity | ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors. | | in vitro | previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1]. | | in vivo | in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2]. | | Purification Methods | Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.] | | references | [1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55. |
| | PROXYPHYLLINE Preparation Products And Raw materials |
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