ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Methylpyrimidine 2,4-Dichloro-5-methylpyrimidine

2,4-Dichloro-5-methylpyrimidine

2,4-Dichloro-5-methylpyrimidine Basic information
Product Name:2,4-Dichloro-5-methylpyrimidine
Synonyms:2,4-dichloro-5-methyl-pyrimidin;2,4-Dichloro-5-methyl-1,3-diazine;Dichloro-5-MethylpyriMid;2,4-DICHLORO-5-METHYLPYRIMIDINE;2,4-Dichloro-5-methylpyrimidine **Toxic, Stench**;Toxic,stench;PYRIMIDINE,2,4-DICHLORO-5-METHYL;2,4-Dichloro-5-
CAS:1780-31-0
MF:C5H4Cl2N2
MW:163
EINECS:217-227-8
Product Categories:Heterocycle-Pyrimidine series;C4 to C5;pharmacetical;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Halides;Nucleic acids;Bases & Related Reagents;Nucleotides;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks;Heterocycles;Pyrimidine;Building Blocks;Halogenated;Nucleotides and Nucleosides;Pyrimidines
Mol File:1780-31-0.mol
2,4-Dichloro-5-methylpyrimidine Structure
2,4-Dichloro-5-methylpyrimidine Chemical Properties
Melting point 26-28 °C (lit.)
Boiling point 108-109 °C/11 mmHg (lit.)
density 1.39 g/mL at 25 °C (lit.)
refractive index 1.6300 (estimate)
Fp >230 °F
storage temp. Inert atmosphere,2-8°C
solubility Soluble in chloroform, ether, ethyl acetate and toluene
pka-2.44±0.29(Predicted)
form powder to lump to clear liquid
color White or Colorless to Almost white or Almost colorless
Sensitive Lachrymatory
InChIKeyDQXNTSXKIUZJJS-UHFFFAOYSA-N
CAS DataBase Reference1780-31-0(CAS DataBase Reference)
EPA Substance Registry SystemPyrimidine, 2,4-dichloro-5-methyl- (1780-31-0)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45-27
RIDADR UN 3261 8/PG 2
WGK Germany 3
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29335990
MSDS Information
ProviderLanguage
2,4-Dichloro-5-methylpyrimidine English
SigmaAldrich English
2,4-Dichloro-5-methylpyrimidine Usage And Synthesis
Chemical PropertiesWhite to Off White Low Melting Solid
Uses2,4-Dichloro-5-methylpyrimidine, is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine. It can react with piperidineto produce 2-chloro-5-methyl-4-piperidin-1-yl-pyrimidine. This reaction will need solvent dioxane.
2,4-Dichloro-5-methylpyrimidine Preparation Products And Raw materials
Preparation Products2-Pyrimidinamine, 4-chloro-5-methyl- (9CI)-->Pyrimidine, 2-chloro-4,5-dimethyl- (9CI)-->4-Pyrimidinamine, 2-chloro-5-methyl-N-[(1S)-1-(3-pyridinyl)butyl]--->Pyrimidine, 2,4-difluoro-5-methyl- (9CI)-->2-chloro-5-MethylpyriMidin-4-ol-->2-CHLORO-4-BENZYLAMINO-5-METHYLPYRIMIDINE-->2-chloro-N,5-dimethyl-pyrimidin-4-amine-->2-hydrazino-5-methyl-4-(2-thienyl)pyrimidine-->5-(2-chloro-5-MethylpyriMidin-4-ylaMino)benzo[d]oxazol-2(3H)-one
(9H-FLUOREN-9-YL)METHYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 2,4-Dichloro-5-fluoropyrimidine 2-Chloro-5-chloromethylpyridine Dichloromethylsilane 2,4,6-TRICHLORO-PYRIMIDINE-5-CARBALDEHYDE 2,4-Dichloro-5-nitropyrimidine Dichloromethylphenylsilane Dichloroacetic acid 5-Methylpyrimidine 2,4-Dichloro-5-methylpyrimidine 2,4-Dichloropyrimidine 4,6-Dichloropyrimidine Fluorocytosine 2,4-Dichloro-5-cyanopyrimidine Pirimiphos-methyl 2,4-Dichloro-5-pyrimidinecarbonyl chloride 4-Ethyl-5-fluoro-6-hydroxypyrimidine Dichlorodimethylsilane
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